Literature DB >> 4524624

The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.

B C Halpern, B R Clark, D N Hardy, R M Halpern, R A Smith.   

Abstract

In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.

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Year:  1974        PMID： 4524624      PMCID： PMC388177          DOI： 10.1073/pnas.71.4.1133

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Amino acid metabolism in mammalian cell cultures.

Authors:  H EAGLE
Journal:  Science       Date:  1959-08-21       Impact factor: 47.728

Review 2.  THE FUNCTION OF VITAMIN B12 AND FOLIC ACID COENZYMES IN MAMMALIAN CELLS.

Authors:  J M BUCHANAN
Journal:  Medicine (Baltimore)       Date:  1964-11       Impact factor: 1.889

3.  Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau).

Authors:  V I OYAMA; H EAGLE
Journal:  Proc Soc Exp Biol Med       Date:  1956-02

4.  The biological synthesis of "labile methyl group".

Authors:  V du VIGNEAUD; C RESSLER; J R RACHELE
Journal:  Science       Date:  1950-09-08       Impact factor: 47.728

5.  Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes.

Authors:  W Kreis; C Hession
Journal:  Cancer Res       Date:  1973-08       Impact factor: 12.701

6.  Dependence of 5-methyltetrahydrofolate utilization by L5178Y murine leukemia cells in vitro on the presence of hydroxycobalamin and transcobalamin II.

Authors:  P L Chello; J R Bertino
Journal:  Cancer Res       Date:  1973-08       Impact factor: 12.701

7.  Vitamin B 12 dependent methionine biosynthesis in cultured mammalian cells.

Authors:  J H Mangum; B K Murray; J A North
Journal:  Biochemistry       Date:  1969-09       Impact factor: 3.162

8.  Deranged B 12 metabolism: studies of fibroblasts grown in tissue culture.

Authors:  S H Mudd; B W Uhlendorf; K R Hinds
Journal:  Biochem Med       Date:  1970-11

9.  A derangement in B 12 metabolism leading to homocystinemia, cystathioninemia and methylmalonic aciduria.

Authors:  S H Mudd; H L Levy; R H Abeles; J P Jennedy
Journal:  Biochem Biophys Res Commun       Date:  1969-04-10       Impact factor: 3.575

10.  Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells.

Authors:  D Kamely; J W Littlefield; R W Erbe
Journal:  Proc Natl Acad Sci U S A       Date:  1973-09       Impact factor: 11.205
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  53 in total

1.  Studies on N5-methyltetrahydrofolate-homocystein methyltransferase in normal and leukemia leukocytes.

Authors:  R Peytremann; J Thorndike; W S Beck
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

2.  Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation.

Authors:  R M Hoffman; S J Jacobsen; R W Erbe
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

3.  Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression.

Authors:  Elena Strekalova; Dmitry Malin; David M Good; Vincent L Cryns
Journal:  Clin Cancer Res       Date:  2015-02-27       Impact factor: 12.531

4.  Amino acid and vitamin requirements in mammalian cultured cells.

Authors:  K Yamamoto; A Niwa
Journal:  Amino Acids       Date:  1993-02       Impact factor: 3.520

5.  A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients.

Authors:  Wei-Xin Cao; Qin-Min Cheng; Xu-Feng Fei; Shu-Fa Li; Hao-Ran Yin; Yan-Zhen Lin
Journal:  World J Gastroenterol       Date:  2000-04       Impact factor: 5.742

6.  Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.

Authors:  Wupeng Yan; Everett Stone; Yan Jessie Zhang
Journal:  Biochemistry       Date:  2017-02-03       Impact factor: 3.162

7.  Differences in cell death in methionine versus cysteine depletion.

Authors:  Katherine F Wallis; Lauren C Morehead; Jordan T Bird; Stephanie D Byrum; Isabelle R Miousse
Journal:  Environ Mol Mutagen       Date:  2021-03-02       Impact factor: 3.216

8.  A critical intracellular concentration of fully reduced non-methylated folate polyglutamates prevents macrocytosis and diminished growth rate of human cell line K562 in culture.

Authors:  D Watkins; B A Cooper
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

9.  Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells.

Authors:  Keith Booher; Da-Wei Lin; Stacey L Borrego; Peter Kaiser
Journal:  Cell Cycle       Date:  2012-11-16       Impact factor: 4.534

10.  L-methioninase production by filamentous fungi: I-screening and optimization under submerged conditions.

Authors:  Salwa A Khalaf; Ashraf S A El-Sayed
Journal:  Curr Microbiol       Date:  2008-12-02       Impact factor: 2.188
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