Literature DB >> 4524614

Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis.

E W Voss, J L Winkelhake.   

Abstract

Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to lysergic acid diethylamide secreted only 7S IgG molecules with an average pI of approximately 7.0.

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Year:  1974        PMID: 4524614      PMCID: PMC388162          DOI: 10.1073/pnas.71.4.1061

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  10 in total

1.  The secretion of antibody by isolated lymph node cells.

Authors:  E HELMREICH; M KERN; H N EISEN
Journal:  J Biol Chem       Date:  1961-02       Impact factor: 5.157

2.  In vitro effect of d-lysergic acid diethylamide on immunoglobulin synthesis.

Authors:  E W Voss; J E Babb; P Metzel; J L Winkelhake
Journal:  Biochem Biophys Res Commun       Date:  1973-02-05       Impact factor: 3.575

3.  Intracellular biosynthesis of rabbit antibody.

Authors:  E W Voss; D C Bauer
Journal:  J Biol Chem       Date:  1967-10-10       Impact factor: 5.157

4.  Incorporation of a lysergic acid diethylamide intermediate into antibody protein in vitro.

Authors:  E W Voss; P Metzel; J L Winkelhake
Journal:  Mol Pharmacol       Date:  1973-05       Impact factor: 4.436

5.  Differences in spectral properties and tryptophan content among rabbit anti-2,4-dinitrophenyl antibodies of the gamma G-immunologbulin class.

Authors:  J E McGuigan; H N Eisen
Journal:  Biochemistry       Date:  1968-05       Impact factor: 3.162

Review 6.  Symposium on in vitro studies of the immune response. 3. Biochemical agents affecting the inductive phase of the secondary antibody respose initiated in vitro.

Authors:  C T Ambrose
Journal:  Bacteriol Rev       Date:  1966-06

7.  Studies of 125I trace labeling of immunoglobulin G by chloramine-T.

Authors:  S Sonoda; M Schlamowitz
Journal:  Immunochemistry       Date:  1970-11

8.  Fluorescein. Hapten and antibody active-site probe.

Authors:  D E Lopatin; E W Voss
Journal:  Biochemistry       Date:  1971-01-19       Impact factor: 3.162

9.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

10.  Isoelectric focusing in polyacrylamide gels.

Authors:  P Righetti; J W Drysdale
Journal:  Biochim Biophys Acta       Date:  1971-04-27
  10 in total
  2 in total

Review 1.  Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities.

Authors:  Attila Szabo
Journal:  Front Immunol       Date:  2015-07-14       Impact factor: 7.561

2.  Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.

Authors:  Vanja Dakic; Juliana Minardi Nascimento; Rafaela Costa Sartore; Renata de Moraes Maciel; Draulio B de Araujo; Sidarta Ribeiro; Daniel Martins-de-Souza; Stevens K Rehen
Journal:  Sci Rep       Date:  2017-10-09       Impact factor: 4.379

  2 in total

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