| Literature DB >> 4522796 |
R A Rush, P E Thomas, T Nagatsu, S Udenfriend.
Abstract
Human serum dopamine-beta-hydroxylase (3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase, EC 1.14.17.1) has been measured in a normal adult population by both enzymatic assay and by radioimmunoassay. The levels of enzymatic activity varied over a very wide range from 0.6 units/ml to 85 units/ml. In contrast, the amount of total dopamine-beta-hydroxylase protein present in these samples, as measured by radioimmunoassay, varied only over a 3-fold range: from 11.7 mug/ml to 34.4 mug/ml. From an analysis of the purified enzyme, the percentage of serum dopamine-beta-hydroxylase that was catalytically active was estimated to be small and variable.Entities:
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Year: 1974 PMID： 4522796 PMCID： PMC388117 DOI： 10.1073/pnas.71.3.872
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205