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Literature DB >> 4522791

Requirement of initiation factor 3 in the initiation of polypeptide synthesis with N-acetylphenylalanyl-tRNA.

Abstract

Initiation factor 3 is required, along with initiation factors 1 and 2, for the incorporation of N-acetylphenylalanine into polypeptides and the formation of N-acetylphenylalanylpuromycin. Initiation factor 3 also strongly stimulates the binding of N-acetylphenylalanyl transfer RNA to isolated 30S ribosomal subunits. Phosphocellulose fractions of initiation factor 3 were found to catalyze N-acetylphenylalanine incorporation differentially with different synthetic messenger RNAs not containing any codons for N-formylmethionine. The results suggest that ribosomes recognize the initiator codon only through the initiator transfer RNA.

Entities: Chemical

Mesh：

Substances：

Year: 1974 PMID： 4522791 PMCID： PMC388096 DOI： 10.1073/pnas.71.3.774

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

32 in total

1. Different classes of initiation factors F3 and their dissociation activity.

Authors: M Grunberg-Manago; J C. Rabinowitz; J Dondon; J C. Lelong; F Gros
Journal: FEBS Lett Date: 1971-12-15 Impact factor: 4.124

2. INTERACTION OF RIBOSOMES AND SYNTHETIC POLYRIBONUCLEOTIDES.

Authors: M TAKANAMI; T OKAMOTO
Journal: J Mol Biol Date: 1963-10 Impact factor: 5.469

3. Initiation factor 3 requirement for the formation of initiation complexes with synthetic oligonucleotides.

Authors: D P Suttle; M A Haralson; J M Ravel
Journal: Biochem Biophys Res Commun Date: 1973-03-17 Impact factor: 3.575

Review 4. Protein synthesis.

Authors: R Haselkorn; L B Rothman-Denes
Journal: Annu Rev Biochem Date: 1973 Impact factor: 23.643

5. Secondary structure of bacteriophage f2 ribonucleic acid and the initiation of in vitro protein biosynthesis.

Authors: H F Lodish
Journal: J Mol Biol Date: 1970-06-28 Impact factor: 5.469

6. The initiation of polyphenylalanine synthesis with N-acetylphenylalanyl-tRNA.

Authors: E B Klem; T Nakamoto
Journal: Proc Natl Acad Sci U S A Date: 1968-12 Impact factor: 11.205

7. Translation of the genetic message. VII. Role of initiation factors in formation of the chain initiation complex with Escherichia coli ribosomes.

Authors: K Iwasaki; S Sabol; A J Wahba; S Ochoa
Journal: Arch Biochem Biophys Date: 1968-05 Impact factor: 4.013

4. Restoration by ribosomal protein S1 of the defective translation in a temperature-sensitive mutant of Escherichia coli K-12: characterization and genetic studies.

Authors: H Ohsawa; B Maruo
Journal: J Bacteriol Date: 1976-09 Impact factor: 3.490

5. Effect of initiation factor 3 binding on the 30S ribosomal subunits of Escherichia coli.

Authors: C L Pon; C Gualerzi
Journal: Proc Natl Acad Sci U S A Date: 1974-12 Impact factor: 11.205

5 in total

Requirement of initiation factor 3 in the initiation of polypeptide synthesis with N-acetylphenylalanyl-tRNA.

1. Different classes of initiation factors F3 and their dissociation activity.

2. INTERACTION OF RIBOSOMES AND SYNTHETIC POLYRIBONUCLEOTIDES.

3. Initiation factor 3 requirement for the formation of initiation complexes with synthetic oligonucleotides.

Review 4. Protein synthesis.

5. Secondary structure of bacteriophage f2 ribonucleic acid and the initiation of in vitro protein biosynthesis.

6. The initiation of polyphenylalanine synthesis with N-acetylphenylalanyl-tRNA.

7. Translation of the genetic message. VII. Role of initiation factors in formation of the chain initiation complex with Escherichia coli ribosomes.

8. The activation of 50S and 30S E. coli ribosomes for polyphenylalanine synthesis.

9. Further studies on the initiation of protein synthesis with N-formylmethionine in E. coli extracts.

10. A possible mechanism for initiation of protein synthesis.

1. Inhibitors of protein synthesis V. Irreversible interaction of antibiotics with an initiation complex.

2. Translational specificity of Bacillus stearothermophilus ribosomes.

3. Ribosomal function and its inhibition by antibiotics in prokaryotes.

4. Restoration by ribosomal protein S1 of the defective translation in a temperature-sensitive mutant of Escherichia coli K-12: characterization and genetic studies.

5. Effect of initiation factor 3 binding on the 30S ribosomal subunits of Escherichia coli.