Literature DB >> 45223

Bicarbonate ATP-ase in ciliary body and a theory of Diamox effect on aqueous humor formation.

E Cotlier.   

Abstract

Bicarbonate was found to stimulate ATP breakdown by rabbit or cat ciliary body-iris homogenates. Maximum HCO3- stimulation of ATPase with Tris-Hepes buffer occured at pH 8.0. Acid pH and chloride ions in the media reduced the activity of the HCO3--stimulated ATPase. The Km for ATP was 0.55 mmolar and for HCO3-, 20 mmlar. HCO3- ATPase was not inhibited by acetazolamide added to in vitro. It is postulated that ATPase represents the linkage step of energy donor mechanism and active CT secretion in acid aqueous humors (human, cat.) or HCO3- secretion in alkaline aqueous humor (rabbit, guinea pig). Inhibition of Cl- or HCO3- secretion by acetazolamide results from decreased intracellular HCO3- levels which, in turn, reduces the stimulation of the HCO3- ATPase.

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Year:  1979        PMID： 45223     DOI： 10.1007/bf00154199

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN： 0165-5701            Impact factor:   2.031


  22 in total

1.  Acetazolamide, metabolic acidosis, and intraocular pressure.

Authors:  G Bietti; M Virno; J Pecori-Giraldi
Journal:  Am J Ophthalmol       Date:  1975-09       Impact factor: 5.258

2.  The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of 24Na in these fluids.

Authors:  H DAVSON; C P LUCK
Journal:  J Physiol       Date:  1957-07-11       Impact factor: 5.182

3.  An anion-sensitive ATPase in lizard gastric mucosa.

Authors:  J J de Pont; T Hansen; S L Bonting
Journal:  Biochim Biophys Acta       Date:  1972-07-03

4.  The presence of a HCO 3 - -ATPase in pancreatic tissue.

Authors:  B Simon; R Kinne; G Sachs
Journal:  Biochim Biophys Acta       Date:  1972-09-01

5.  Bicarbonate formation in cerebrospinal fluid: role in sodium transport and pH regulation.

Authors:  T H Maren
Journal:  Am J Physiol       Date:  1972-04

6.  Chloride ion transport in the isolated ciliary body.

Authors:  M G Holland; C C Gipson
Journal:  Invest Ophthalmol       Date:  1970-01

7.  The effect of ouabain and acetazolamide on transport of sodium and chloride from plasma to aqueous humor.

Authors:  L C Garg; W W Oppelt
Journal:  J Pharmacol Exp Ther       Date:  1970-11       Impact factor: 4.030

8.  Proline transport by rabbit ciliary body-iris in vitro.

Authors:  L A Coben; E Cotlier; C Beaty; B Becker
Journal:  Invest Ophthalmol       Date:  1970-12

9.  Energy dependence of urinary bicarbonate secretion in turtle bladder.

Authors:  J A Oliver; S Himmelstein; P R Steinmetz
Journal:  J Clin Invest       Date:  1975-05       Impact factor: 14.808

10.  The rates of ion movement from plasma to aqueous humor in the dogfish, Squalus acanthias.

Authors:  T H Maren; P Wistrand; E R Swenson; A B Talalay
Journal:  Invest Ophthalmol       Date:  1975-09
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  1 in total

1.  Effect of potassium channel openers in acute and chronic models of glaucoma.

Authors:  Shital S Panchal; Anita A Mehta; Devdas D Santani
Journal:  Taiwan J Ophthalmol       Date:  2016-06-20
  1 in total

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