Literature DB >> 452180

Ureterosigmoidostomy in rats: a model for the study of bladder tumour carcinogenesis and cocarcinogenesis.

R G Rowland, J T Grayhack, R Oyasu.   

Abstract

A modified Coffey I ureterosigmoidostomy has been developed in rats as a model of urinary diversion for studying bladder carcinogenesis and co-carcinogenesis. Diverted and sham-operated animals were killed at 1, 3 and 6 months. Excretory urograms revealed minimal hydroureteronephrosis in most diverted animals. Upper tract bacterial colonisation was 9 times more frequent in diverted animals. Approximately one-third of the diverted animals had focal cortical scarring; however, renal function was normal in all groups as assessed by serum creatinine and electrolytes. These studies indicate that ureterosigmoidostomy in rats is a satisfactory model of urinary diversion for studying carcinogenesis.

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Year:  1979        PMID： 452180     DOI： 10.1007/bf00262922

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  14 in total

1.  Five years' experience with uretero-enterostomy by the combined technique.

Authors:  W F LEADBETTER; B G CLARKE
Journal:  J Urol       Date:  1955-01       Impact factor: 7.450

2.  A study of the carcinogenic effect of beta-naphthylamine on the normal and substituted isolated sigmoid loop bladder of dogs.

Authors:  W W SCOTT; H L BOYD
Journal:  J Urol       Date:  1953-12       Impact factor: 7.450

3.  The role of the urine in vesical neoplasm. I. Experimental confirmation of the urogenous theory of pathogenesis.

Authors:  D F McDONALD; R R LUND
Journal:  J Urol       Date:  1954-05       Impact factor: 7.450

4.  Disappearance of carcinomatous ulceration of bladder following ureterosigmoidostomy; report of two cases.

Authors:  E DAVIS
Journal:  J Am Med Assoc       Date:  1948-05-29

5.  Consideration of problems incident to performance of uretero-enterostomy: report of a technique.

Authors:  W F LEADBETTER
Journal:  J Urol       Date:  1951-05       Impact factor: 7.450

6.  Spontaneous disappearance or retrogression of bladder neoplasm; review of the literature and report of three cases.

Authors:  B S ABESHOUSE; I SCHERLIS
Journal:  Urol Cutaneous Rev       Date:  1951-01

7.  In vivo transplantability of urinary bladder epithelia from rats ingesting N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide.

Authors:  S Yalciner; A J Tiltman; G H Friedell
Journal:  J Natl Cancer Inst       Date:  1973-10       Impact factor: 13.506

8.  The use of N-(4-(5-nitro-2-furyl)-2-thiazolyl) formamide in the study of bladder cancer.

Authors:  A J Tiltman
Journal:  S Afr Med J       Date:  1972-03-11

9.  Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide.

Authors:  E Ertürk; S M Cohen; J M Price; G T Bryan
Journal:  Cancer Res       Date:  1969-12       Impact factor: 12.701

10.  [Therapeutic indications in malignant bladder tumors].

Authors:  P Auvray
Journal:  Acta Urol Belg       Date:  1971-01
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  1 in total

1.  A simple method for in vitro studies with rodent urinary bladders.

Authors:  C D Jackson; G Newport
Journal:  In Vitro       Date:  1981-02
  1 in total

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