Literature DB >> 4521045

Effects of 5-hydroxykynurenamine, a new serotonin metabolite, on isolated dog basilar arteries.

N Toda, T Tokuyama, S Seno, F Hirata, O Hayaishi.   

Abstract

Serotonin and 5-hydroxykynurenamine caused dose-related contractions in the spiral strips of dog basilar arteries. The potency of 5-hydroxykynurenamine was approximately 1/100 that of serotonin, the former frequently causing a transient relaxation preceding the contraction. The contractile responses to 5-hydroxykynurenamine and serotonin were attenuated by methysergide. Treatment with 5-hydroxykynurenamine inhibited the response to serotonin, and this inhibitory effect was not completely reversed by removal of 5-hydroxykynurenamine from the bathing medium. The contractile response to K(+) was only slightly attenuated by high concentrations of 5-hydroxykynurenamine. It appears that 5-hydroxykynurenamine and serotonin share receptors in dog basilar arteries and that the effect of serotonin is specifically antagonized by 5-hydroxykynurenamine.

Entities:  

Mesh：

Substances：

Year:  1974        PMID： 4521045      PMCID： PMC387947          DOI： 10.1073/pnas.71.1.122

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  5 in total

1.  Direct tension recording from smooth muscle of resistance vessels from various organs.

Authors:  D F BOHR; P L GOULET; A C TAQUINI
Journal:  Angiology       Date:  1961-10       Impact factor: 3.619

2.  Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat.

Authors:  K C Nielsen; C Owman
Journal:  Brain Res       Date:  1971-03-19       Impact factor: 3.252

3.  New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase.

Authors:  F Hirata; O Hayaishi
Journal:  Biochem Biophys Res Commun       Date:  1972-06-09       Impact factor: 3.575

4.  Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine, and transmural electrical stimulation.

Authors:  N Toda; Y Fujita
Journal:  Circ Res       Date:  1973-07       Impact factor: 17.367

5.  Cardiovascular effects of capsaicin in dogs and rabbits.

Authors:  N Toda; H Usui; N Nishino; M Fujiwara
Journal:  J Pharmacol Exp Ther       Date:  1972-06       Impact factor: 4.030
  5 in total
  5 in total

1.  No evidence for a physiological role of 5-hydroxykynuramine in chicken hemostasis.

Authors:  G L Laekeman; M Claeys; M Vrints; A G Herman
Journal:  Agents Actions       Date:  1985-07

2.  Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine.

Authors:  M Fujiwara; M Shibata; Y Nomiyama; T Sugimoto; F Hirata; T Tokuyama; S Senoh; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

3.  Evidence for presence of kynurenine in lung and brain of neonate hamsters.

Authors:  I M Keith; M S Brownfield
Journal:  Histochemistry       Date:  1985

4.  Effects of 5-hydroxytryptophol, a 5-hydroxytryptamine metabolite, on isolated cerebral arteries of the dog.

Authors:  L H Wang Fu; S Hayashi; N Toda
Journal:  Br J Pharmacol       Date:  1980-01       Impact factor: 8.739

5.  Antagonism of 5-hydroxykynurenamine against serotonin action on platelet aggregation.

Authors:  M Okuma; T Tokuyama; S Senoh; F Hirata; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.