Literature DB >> 4517947

Structual comparison of ectopic and normal placental alkaline phosphatase.

P J Greene, H H Sussman.   

Abstract

An alkaline phosphatase immunochemically similar to placental alkaline phosphatase (EC 3.1.3.1) was purified from liver metastases of a giant-cell carcinoma of the lung. Some properties of its physical and chemical structure were determined and compared to those of purified placental alkaline phosphatase. The purified tumor phosphatase and the placental phosphatase were similar with regard to the following properties: (1) NH(2)-terminal sequence, (2) peptide map, (3) subunit molecular weight, and (4) isoelectric point. The physical properties and NH(2)-terminal sequence of alkaline phosphatase isoenzyme of liver differed from the placental and the tumor enzyme. The data from the present study strongly support the hypothesis that the tumor and the placental alkaline phosphatases are products of the same gene.

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Year:  1973        PMID： 4517947      PMCID： PMC427142          DOI： 10.1073/pnas.70.10.2936

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Humoral syndromes associated with cancer.

Authors:  M B Lipsett
Journal:  Cancer Res       Date:  1965-08       Impact factor: 12.701

2.  Human placental alkaline phosphatase: molecular weight and subunit structure.

Authors:  A J Gottlieb; H H Sussman
Journal:  Biochim Biophys Acta       Date:  1968-06-26

3.  Studies on human placental alkaline phosphatase. II. Kinetic properties and studies on the apoenzyme.

Authors:  D R Harkness
Journal:  Arch Biochem Biophys       Date:  1968-08       Impact factor: 4.013

4.  Human alkaline phosphatase. Immunochemical identification of organ-specific isoenzymes.

Authors:  H H Sussman; P A Small; E Cotlove
Journal:  J Biol Chem       Date:  1968-01-10       Impact factor: 5.157

5.  A simple apparatus for vertical flat-sheet polyacrylamide gel electrophoresis.

Authors:  M S Reid; R L Bieleski
Journal:  Anal Biochem       Date:  1968-03       Impact factor: 3.365

6.  A simple apparatus and procedure for electrofocusing experiments: pL of lactate dehydrogenase and isocitrate lyase.

Authors:  D L Weller; A Heaney; R E Sjogren
Journal:  Biochim Biophys Acta       Date:  1968-12-03

7.  Gonadotropin secretion from a bronchogenic carcinoma. Demonstration by radioimmunoassay.

Authors:  C Faiman; J A Colwell; R J Ryan; J M Hershman; T W Shields
Journal:  N Engl J Med       Date:  1967-12-28       Impact factor: 91.245

8.  Isoelectric fractionation, analysis, and characterization of ampholytes in natural pH gradients. IV. Further studies on the resolving power in connection with separation of myoglobins.

Authors:  O Vesterberg; H Svensson
Journal:  Acta Chem Scand       Date:  1966

9.  Genetics of the alkaline phosphatase polymorphism of the human placenta.

Authors:  E B Robson; H Harris
Journal:  Nature       Date:  1965-09-18       Impact factor: 49.962

10.  Radioimmunoassay for human luteinizing hormone.

Authors:  W D Odell; G T Ross; P L Rayford
Journal:  Metabolism       Date:  1966-04       Impact factor: 8.694
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  14 in total

1.  Synthesis of alpha subunit of human chorionic gonadotrophin by presumptive HeLa cells.

Authors:  J Y Chou; B D Weintraub; S W Rosen; J Whangpeng; H D Sussman; J R Haughom; J C Robinson
Journal:  In Vitro       Date:  1976-08

2.  Regulation of alkaline phosphatase expression in human choriocarcinoma cell lines.

Authors:  T A Hamilton; A W Tin; H H Sussman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

3.  Establishment of clonal human placental cells synthesizing human choriogonadotropin.

Authors:  J Y Chou
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Affinity purification and some molecular properties of human liver alkaline phosphatase.

Authors:  J M Trépanier; L E Seargeant; R A Stinson
Journal:  Biochem J       Date:  1976-06-01       Impact factor: 3.857

5.  Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.

Authors:  C E Ovitt; A W Strauss; D H Alpers; J Y Chou; I Boime
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

6.  Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas.

Authors:  H Galski; S E Fridovich; D Weinstein; N De Groot; S Segal; R Folman; A A Hochberg
Journal:  Biochem J       Date:  1981-03-15       Impact factor: 3.857

7.  Human cell lines expressing intestinal alkaline phosphatase.

Authors:  F J Benham; H Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

8.  Tumour production of alkaline phosphatase in a patient with giant-cell carcinoma of bronchus.

Authors:  J M Pfeffer; P G Stovin
Journal:  Thorax       Date:  1978-04       Impact factor: 9.139

9.  Structural evidence that human liver and placental alkaline phosphatase isoenzymes are coded by different genes.

Authors:  K S Badger; H H Sussman
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

10.  The effect of bromodeoxyuridine and dibutyryl cyclic AMP on the induction of placental alkaline phosphate in human choriocarcinoma cells.

Authors:  T A Hamilton; H H Sussman
Journal:  Biochem J       Date:  1981-07-15       Impact factor: 3.857
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