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Literature DB >> 451608

Ketone bodies are selectively used by individual brain regions.

Abstract

Close study of 3-hydroxybutyrate uptake by brain suggests that its metabolism is limited by permeability. Furthermore, the permeability characteristics vary from region to region; areas known to have no blood-brain barrier show the highest rate of utilization. The results imply that rather than substitute fuels, ketone bodies should be considered supplements which partially supply specific areas but are incapable of supporting the entire energy requirement of all brain regions.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 451608 DOI： 10.1126/science.451608

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

38 in total

Review 1. Molecular and physiological responses to juvenile traumatic brain injury: focus on growth and metabolism.

Authors: Talin Babikian; Mayumi L Prins; Yan Cai; Garni Barkhoudarian; Ivet Hartonian; David A Hovda; Christopher C Giza
Journal: Dev Neurosci Date: 2010-11-12 Impact factor: 2.984

2. Fenofibrate prevents skeletal muscle loss in mice with lung cancer.

Authors: Marcus D Goncalves; Seo-Kyoung Hwang; Chantal Pauli; Charles J Murphy; Zhe Cheng; Benjamin D Hopkins; David Wu; Ryan M Loughran; Brooke M Emerling; Guoan Zhang; Douglas T Fearon; Lewis C Cantley
Journal: Proc Natl Acad Sci U S A Date: 2018-01-08 Impact factor: 11.205

3. Competition of glycerol with other oxidizable substrates in rat brain.

Authors: M C McKenna; L I Bezold; S J Kimatian; J T Tildon
Journal: Biochem J Date: 1986-07-01 Impact factor: 3.857

Review 4. Cerebral metabolic adaptation and ketone metabolism after brain injury.

Authors: Mayumi L Prins
Journal: J Cereb Blood Flow Metab Date: 2007-08-08 Impact factor: 6.200

Review 5. β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.

Authors: Lavanya B Achanta; Caroline D Rae
Journal: Neurochem Res Date: 2016-11-08 Impact factor: 3.996

6. Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern.

Authors: M I Bird; L A Munday; E D Saggerson; J B Clark
Journal: Biochem J Date: 1985-02-15 Impact factor: 3.857

Ketone bodies are selectively used by individual brain regions.

Review 1. Molecular and physiological responses to juvenile traumatic brain injury: focus on growth and metabolism.

2. Fenofibrate prevents skeletal muscle loss in mice with lung cancer.

3. Competition of glycerol with other oxidizable substrates in rat brain.

Review 4. Cerebral metabolic adaptation and ketone metabolism after brain injury.

Review 5. β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.

6. Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern.

Review 7. Supply and demand in cerebral energy metabolism: the role of nutrient transporters.

8. Competition among oxidizable substrates in brains of young and adult rats. Whole homogenates.

9. Transport of nutrients and hormones through the blood-brain barrier.

10. Regional enzyme development in rat brain. Enzymes of energy metabolism.