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Literature DB >> 4515929

Effects of a snake alpha-neurotoxin on the development of innervated skeletal muscles in chick embryo.

G Giacobini, G Filogamo, M Weber, P Boquet, J P Changeux.

Abstract

The evolution of the cholinergic (nicotinic) receptor in chick muscles is monitored during embryonic development with a tritiated alpha-neurotoxin from Naja nigricollis and compared with the appearance of acetylcholinesterase. The specific activity of these two proteins reaches a maximum around the 12th day of incubation. By contrast, choline acetyltransferase reaches an early maximum of specific activity around the 7th day of development, and later continuously increases until hatching. Injection of alpha-toxin in the yolk sac at early stages of development causes an atrophy of skeletal and extrinsic ocular-muscles and of their innervation. In 16-day embryos treated by the alpha-toxin, the endplates revealed by the Koelle reaction are almost completely absent. The total content and specific activities of acetylcholinesterase and choline acetyltransferase in atrophic muscles are markedly reduced.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1973 PMID： 4515929 PMCID： PMC433578 DOI： 10.1073/pnas.70.6.1708

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

36 in total

1. Tritium labelling of the alpha-neurotoxin of Naja nigricollis.

Authors: A Menez; J -L. Morgat; P Fromageot; A -M. Ronseray; P Boquet; J -P. Changeux
Journal: FEBS Lett Date: 1971-10-01 Impact factor: 4.124

2. EFFECTS OF SPINAL CORD AND SUBSTRATE ON ACETYLCHOLINESTERASE IN CHICK EMBRYONIC SKELETAL MUSCLE.

Authors: B C GOODWIN; I W SIZER
Journal: Dev Biol Date: 1965-02 Impact factor: 3.582

3. MICRODETERMINATION OF CHOLINE ACETYLASE IN NERVOUS TISSUE.

Authors: R E MCCAMAN; J M HUNT
Journal: J Neurochem Date: 1965-04 Impact factor: 5.372

4. [Comparative study of the cholinesterase content of striated muscle, heart and smooth muscle during the development of the chick embryo].

Authors: A MILLO
Journal: Riv Biol Date: 1961 Apr-Jun

Review 5. Comparison between the effect of neuronal activity and nerve growth factor on the enzymes involved in the synthesis of norepinephrine.

Authors: H Thoenen
Journal: Pharmacol Rev Date: 1972-06 Impact factor: 25.468

6. Trans-synaptic induction of adrenal tyrosine hydroxylase.

Authors: H Thoenen; R A Mueller; J Axelrod
Journal: J Pharmacol Exp Ther Date: 1969-10 Impact factor: 4.030

7. Development of acetylcholine receptor clusters on cultured muscle cells.

Authors: A J Sytkowski; Z Vogel; M W Nirenberg
Journal: Proc Natl Acad Sci U S A Date: 1973-01 Impact factor: 11.205

8. Neural correlates of embryonic motility in the chick.

Authors: K L Ripley; R R Provine
Journal: Brain Res Date: 1972-10-13 Impact factor: 3.252

9. [Effect of cholinergic agents and local anesthetics on the kinetics of binding of tritiated toxin of Naja nigricollis to the cholinergic receptor].

Authors: M Weber; A Menez; P Fromageot; P Boquet; J P Changeux
Journal: C R Acad Hebd Seances Acad Sci D Date: 1972-03-06

10. Appearance of acetylcholine receptors during differentiation of a myogenic cell line.

Authors: J Patrick; S F Heinemann; J Lindstrom; D Schubert; J H Steinbach
Journal: Proc Natl Acad Sci U S A Date: 1972-10 Impact factor: 11.205

17 in total

1. Synapse and acetylcholine receptor synthesis by neurons dissociated from retina.

Authors: Z Vogel; M P Daniels; M Nirenberg
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

2. Enzymatic activities of muscle fibres differentiated, in vitro, from pectoralis major (white) and adductor magnus (red) muscles of chick embryos.

Authors: J Nouguès; F Bacou
Journal: Experientia Date: 1977-06-15

Effects of a snake alpha-neurotoxin on the development of innervated skeletal muscles in chick embryo.

1. Tritium labelling of the alpha-neurotoxin of Naja nigricollis.

2. EFFECTS OF SPINAL CORD AND SUBSTRATE ON ACETYLCHOLINESTERASE IN CHICK EMBRYONIC SKELETAL MUSCLE.

3. MICRODETERMINATION OF CHOLINE ACETYLASE IN NERVOUS TISSUE.

4. [Comparative study of the cholinesterase content of striated muscle, heart and smooth muscle during the development of the chick embryo].

Review 5. Comparison between the effect of neuronal activity and nerve growth factor on the enzymes involved in the synthesis of norepinephrine.

6. Trans-synaptic induction of adrenal tyrosine hydroxylase.

7. Development of acetylcholine receptor clusters on cultured muscle cells.

8. Neural correlates of embryonic motility in the chick.

9. [Effect of cholinergic agents and local anesthetics on the kinetics of binding of tritiated toxin of Naja nigricollis to the cholinergic receptor].

10. Appearance of acetylcholine receptors during differentiation of a myogenic cell line.

1. Synapse and acetylcholine receptor synthesis by neurons dissociated from retina.

2. Enzymatic activities of muscle fibres differentiated, in vitro, from pectoralis major (white) and adductor magnus (red) muscles of chick embryos.

Review 3. Activity-dependent regulation of gene expression in muscle and neuronal cells.

4. Differentiation of cell membranes in cultures of embryonic chick breast muscle.

5. Differentiation of cultured muscle in the presence of alpha-bungarotoxin.

6. In vivo development of cholinesterase at a neuromuscular junction in the absence of motor activity in Xenopus laevis.

7. Re-innervation of rat skeleton muscle in the presence of alpha-bungarotoxin.

8. Role of innervation on the embryonic development of skeletal muscle.

9. Control of junctional acetylcholinesterase by neural and muscular influences in the rat.

10. The development of motor projection patterns in the chick hind limb.