| Literature DB >> 4515616 |
Abstract
Material that increases black lipid-membrane (oxidized cholesterol) conductance has been demonstrated in the acid-soluble fraction of tryptic digests of membrane fractions from Electrophorus electric organ and beef kidney. The conductance change elicited by this material is highly selective for Na(+). The activity of the material was greatly enhanced by passage through DEAE-cellulose. Activity could be destroyed by further incubation with Pronase. Since conductivity increases exponentially with dose of ionophore, the conductive unit may be an oligomer.Entities:
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Year: 1973 PMID: 4515616 PMCID: PMC433455 DOI: 10.1073/pnas.70.4.1191
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205