Literature DB >> 451556

GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization.

J A DiMicco, K Gale, B Hamilton, R A Gillis.   

Abstract

Blockade of gamma-aminobutyric acid (GABA) receptor function by direct microinjection of the GABA receptor antagonist bicuculline into the nucleus ambiguus of the brainstem produced a marked, dose-related depression of heart rate and blood pressure which was mediated by the vagus nerve. This effect was not obtained in other regions of the brainstem and was reversed by the GABA receptor agonist muscimol. These data indicate that the nucleus ambiguus may be the site of a GABA receptor-mediated inhibition of vagal outflow.

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Year:  1979        PMID： 451556     DOI： 10.1126/science.451556

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Time course of effects of 3-mercaptopropionic acid on GABA levels in different brain regions in guinea pigs: possible relationship with associated cardiovascular changes.

Authors:  N L Alsip; J A DiMicco
Journal:  Neurochem Res       Date:  1992-05       Impact factor: 3.996

Review 2.  Major Autonomic Neuroregulatory Pathways Underlying Short- and Long-Term Control of Cardiovascular Function.

Authors:  Ibrahim M Salman
Journal:  Curr Hypertens Rep       Date:  2016-03       Impact factor: 5.369

3.  Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid.

Authors:  Stephanie C Tjen-A-Looi; Peng Li; Min Li; John C Longhurst
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-12-28       Impact factor: 3.619

Review 4.  Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.

Authors:  M J Iadarola; K Gale
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

5.  Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS.

Authors:  P Bousquet; J Feldman; R Bloch; J Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-05       Impact factor: 3.000

6.  Distribution and uptake of glycine, glutamate and gamma-aminobutyric acid in the vagal nuclei and eight other regions of the rat medulla oblongata.

Authors:  E R Siemers; M A Rea; D L Felten; M H Aprison
Journal:  Neurochem Res       Date:  1982-04       Impact factor: 3.996

Review 7.  Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.

Authors:  A V Christensen; O Svendsen; P Krogsgaard-Larsen
Journal:  Pharm Weekbl Sci       Date:  1982-10-22

Review 8.  Innervation of the heart: An invisible grid within a black box.

Authors:  Suraj Kapa; Christopher V DeSimone; Samuel J Asirvatham
Journal:  Trends Cardiovasc Med       Date:  2015-07-09       Impact factor: 6.677

9.  Age-dependent changes in cardiovascular responses induced by muscimol infused into the nucleus tractus solitarii and nucleus parabrachialis medialis in rats.

Authors:  V Mollace; E A De Francesco; G Fersini; G Nistico
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

10.  Somatosensory and hypothalamic inhibitions of baroreflex vagal bradycardia in rats.

Authors:  S Nosaka; N Nakase; K Murata
Journal:  Pflugers Arch       Date:  1989-04       Impact factor: 3.657
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