Literature DB >> 4514987

Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine.

J J Kamm, T Dashman, A H Conney, J J Burns.   

Abstract

The oral treatment of rats with sodium ascorbate in combination with sodium nitrite and aminopyrine prevents the rise in serum alanine aminotransferase (EC 2.6.1.2) observed when nitrite and aminopyrine are given alone. Ascorbic acid also affords protection, whereas dehydroascorbic acid exerts no protective effect.

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Year:  1973        PMID： 4514987      PMCID： PMC433349          DOI： 10.1073/pnas.70.3.747

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  Symposium on metabolism of inorganic compounds. II. Enzymatic pathways of nitrate, nitrite, and hydroxylamine metabolisms.

Authors:  A NASON
Journal:  Bacteriol Rev       Date:  1962-03

2.  A nitrate reductase from Micrococcus denitrificans.

Authors:  Y Lam; D J Nicholas
Journal:  Biochim Biophys Acta       Date:  1969-04-22

3.  Carcinogen dimethylnitrosamine produced in vivo from nitrite and aminopyrine.

Authors:  W Lijinsky; M Greenblatt
Journal:  Nat New Biol       Date:  1972-04-12

Review 4.  Carcinogenic nitroso compounds.

Authors:  P N Magee; J M Barnes
Journal:  Adv Cancer Res       Date:  1967       Impact factor: 6.242

5.  Nitrates, nitrites, and nitrosamines.

Authors:  I A Wolff; A E Wasserman
Journal:  Science       Date:  1972-07-07       Impact factor: 47.728

6.  Nitrosamines as environmental carcinogens.

Authors:  W Lijinsky; S S Epstein
Journal:  Nature       Date:  1970-01-03       Impact factor: 49.962

Review 7.  Toxicity of nitrosamines: their possible human health hazards.

Authors:  P N Magee
Journal:  Food Cosmet Toxicol       Date:  1971-04

8.  Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds.

Authors:  S S Mirvish; L Wallcave; M Eagen; P Shubik
Journal:  Science       Date:  1972-07-07       Impact factor: 47.728
  8 in total
  6 in total

1.  Carcinogenic N-nitro-dimethylamine from the reaction of the analgesic amidopyrine and nitrite extracted from foodstuffs.

Authors:  J LaBar; J Sander
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1975-11-25

2.  Kinetics of the nitrosation of aminopyrine to give dimethylnitrosamine.

Authors:  S S Mirvish; B Gold; M Eagen; S Arnold
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1974

3.  [Ascorbic acid hinderance of the prenatal carcinogenic effect of ethylurea and nitrite].

Authors:  S Ivankovic; W J Zeller; D Schmähl; R Preussmann
Journal:  Naturwissenschaften       Date:  1973-11

4.  Transaminase level (GOT, GPT) in rats under treatment with diethylnitrosamine.

Authors:  D Schmähl; M Spielmann
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1975

5.  Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model.

Authors:  Hideaki Yada; Masao Hirose; Seiko Tamano; Mayumi Kawabe; Masashi Sano; Satoru Takahashi; Mitsuru Futakuchi; Tokutaro Miki; Tomoyuki Shirai
Journal:  Jpn J Cancer Res       Date:  2002-12

6.  Some EPR signals in tumour tissue.

Authors:  N J Dodd
Journal:  Br J Cancer       Date:  1973-09       Impact factor: 7.640
  6 in total

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