| Literature DB >> 451353 |
J T Miyahara, C K Akau, T Yasumoto.
Abstract
The effects of ciguatoxin (CT) and maitotoxin (MT) were studied on the isolated atria of the guinea pig. Application of CT evoked a prolonged positive inotropic effect on the electrically-driven atria and both inotropic and chronotropic effects on the spontaneously-beating right atria. The response to MT in contrast was biphasic. At low concentration (10(-8) Gm per ml) MT enhanced the atrial contractility, while at higher concentrations (5 x 10(-8) Gm per ml) it depressed the atria and frequently to a standstill. The results indicate that CT and MT have a direct action on the contractile mechanism of the heart and their effects are readily distinguishable.Entities:
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Year: 1979 PMID： 451353
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164