Literature DB >> 4511871

Peripheral cardiovascular effects, in the pithed rat, of compounds used in the treatment of hypertension.

K M Dhasmana, W A Fokker, B A Spilker.   

Abstract

A method for stimulating discrete segments of the spinal autonomic outflow in the pithed rat was found suitable for differentiating between the group of centrally acting antihypertensive agents alpha-methyldopa, clonidine and iproniazid and other antihypertensive compounds which additionally have peripheral vascular effects mediated via the peripheral sympathetic nerves.

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Year:  1972        PMID： 4511871      PMCID： PMC1666500          DOI： 10.1111/j.1476-5381.1972.tb08148.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  2 in total

1.  A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat.

Authors:  J S Gillespie; T C Muir
Journal:  Br J Pharmacol Chemother       Date:  1967-05

2.  A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.

Authors:  J S Gillespie; A Maclaren; D Pollock
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739
  2 in total
  1 in total

1.  Effects of clonidine and guanethidine on peripheral sympathetic nerve function in the pithed rat.

Authors:  J M Armstrong; A L Boura
Journal:  Br J Pharmacol       Date:  1973-04       Impact factor: 8.739
  1 in total

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