Literature DB >> 4509646

The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A.

R C Rosenberg, C A Root, R H Wang, M Cerdonio, H B Gray.   

Abstract

The magnetic susceptibilities of cobalt(II) and nickel(II) derivaties of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 +/- 0.15 and 2.53 +/- 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.

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Year:  1973        PMID： 4509646      PMCID： PMC433206          DOI： 10.1073/pnas.70.1.161

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  PROCEDURES FOR THE ISOLATION OF CRYSTALLINE BOVINE PANCREATIC CARBOXYPEPTIDASE A. II. ISOLATION OF CARBOXYPEPTIDASE A-ALPHA FROM PROCARBOXYPEPTIDASE A.

Authors:  D J COX; F C BOVARD; J P BARGETZI; K A WALSH; H NEURATH
Journal:  Biochemistry       Date:  1964-01       Impact factor: 3.162

2.  Metallocarboxypeptidases: stability constants and enzymatic characteristics.

Authors:  J E COLEMAN; B L VALLEE
Journal:  J Biol Chem       Date:  1961-08       Impact factor: 5.157

3.  Metallocarboxypeptidases.

Authors:  J E COLEMAN; B L VALLEE
Journal:  J Biol Chem       Date:  1960-02       Impact factor: 5.157

4.  The structure of carboxypeptidase A. 8. Atomic interpretation at 0.2 nm resolution, a new study of the complex of glycyl-L-tyrosine with CPA, and mechanistic deductions.

Authors:  W N Lipscomb; G N Reeke; J A Hartsuck; F A Quiocho; P H Bethge
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1970-02-12       Impact factor: 6.237

5.  Spectral properties of cobalt carboxypeptidase. The effects of substrates and inhibitors.

Authors:  S A Latt; B L Vallee
Journal:  Biochemistry       Date:  1971-11       Impact factor: 3.162

6.  Kinetics of carboxypeptidase A. II. Inhibitors of the hydrolysis of oligopeptides.

Authors:  D S Auld; B L Vallee
Journal:  Biochemistry       Date:  1970-02-03       Impact factor: 3.162

7.  The amino acid sequence of bovine carboxypeptidase A.

Authors:  R A Bradshaw; L H Ericsson; K A Walsh; H Neurath
Journal:  Proc Natl Acad Sci U S A       Date:  1969-08       Impact factor: 11.205

8.  Metalloenzymes: the entatic nature of their active sites.

Authors:  B L Vallee; R J Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205
  8 in total
  5 in total

1.  Biomimetic nanostructures: creating a high-affinity zinc-binding site in a folded nonbiological polymer.

Authors:  Byoung-Chul Lee; Tammy K Chu; Ken A Dill; Ronald N Zuckermann
Journal:  J Am Chem Soc       Date:  2008-07-09       Impact factor: 15.419

2.  The activity-related ionization in carbonic anhydrase.

Authors:  D W Appleton; B Sarkar
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

3.  Preparation and spectroscopic studies of cobalt(II)-stellacyanin.

Authors:  D R McMillin; R A Holwerda; H B Gray
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

4.  The influence of anions and inhibitors on the catalytic metal ion in Co(II)-substituted horse liver alcohol dehydrogenase.

Authors:  I Bertini; G Lanini; C Luchinat; C Haas; W Maret; M Zeppezauer
Journal:  Eur Biophys J       Date:  1987       Impact factor: 1.733

5.  Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution.

Authors:  D C Rees; M Lewis; R B Honzatko; W N Lipscomb; K D Hardman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
  5 in total

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