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Literature DB >> 4509329

Partial duplication in the "hinge" region of IgA 1 myeloma proteins.

Abstract

The aminoacid sequence of the "hinge" region of two human IgA(1) myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA(2) myeloma protein, it is possible that IgA(1) molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1972 PMID： 4509329 PMCID： PMC389846 DOI： 10.1073/pnas.69.12.3673

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

14 in total

1. Halogenation of tyrosine during acid hydrolysis.

Authors: F SANGER; E O THOMPSON
Journal: Biochim Biophys Acta Date: 1963-05-14

2. Structure of immunoglobulin A. II. Sequence around the hinge region and labile disulfide bonds of an immunoglobulin A2 myeloma protein.

Authors: C Wolfenstein-Todel; B Frangione; E C Franklin
Journal: Biochemistry Date: 1972-10-10 Impact factor: 3.162

3. The molecular defect in a protein (CRA) found in gamma-1 heavy chain disease, and its genetic implications.

Authors: E C Franklin; B Frangione
Journal: Proc Natl Acad Sci U S A Date: 1971-01 Impact factor: 11.205

4. Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins.

Authors: B Frangione; C Milstein
Journal: J Mol Biol Date: 1968-05-14 Impact factor: 5.469

5. Partial deletion in the heavy chain disease protein ZUC.

Authors: B Frangione; C Milstein
Journal: Nature Date: 1969-11-08 Impact factor: 49.962

6. Structural studies of immunoglobulin G.

Authors: B Frangione; C Milstein; J R Pink
Journal: Nature Date: 1969-01-11 Impact factor: 49.962

7. The covalent structure of an entire gammaG immunoglobulin molecule.

Authors: G M Edelman; B A Cunningham; W E Gall; P D Gottlieb; U Rutishauser; M J Waxdal
Journal: Proc Natl Acad Sci U S A Date: 1969-05 Impact factor: 11.205

8. Structural studies of immunoglobulin G, M and A heavy chains.

Authors: B Frangione; F Prelli; C Mihaesco; C Wolfenstein; E Mihaesco; E C Franklin
Journal: Ann N Y Acad Sci Date: 1971-12-31 Impact factor: 5.691

9. Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups.

Authors: R E Offord
Journal: Nature Date: 1966-08-06 Impact factor: 49.962

10. Molecular defect in a gamma-2 heavy chain.

Authors: S M Cooper; E C Franklin; B Frangione
Journal: Science Date: 1972-04-14 Impact factor: 47.728

26 in total

Review 1. Progress in molecular and genetic studies of IgA nephropathy.

Authors: J Novak; B A Julian; M Tomana; J Mesteck
Journal: J Clin Immunol Date: 2001-09 Impact factor: 8.317

2. Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.

Authors: Michelle M Gomes; Hitoshi Suzuki; Monica T Brooks; Milan Tomana; Zina Moldoveanu; Jiri Mestecky; Bruce A Julian; Jan Novak; Andrew B Herr
Journal: Biochemistry Date: 2010-07-13 Impact factor: 3.162

Partial duplication in the "hinge" region of IgA 1 myeloma proteins.

1. Halogenation of tyrosine during acid hydrolysis.

2. Structure of immunoglobulin A. II. Sequence around the hinge region and labile disulfide bonds of an immunoglobulin A2 myeloma protein.

3. The molecular defect in a protein (CRA) found in gamma-1 heavy chain disease, and its genetic implications.

4. Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins.

5. Partial deletion in the heavy chain disease protein ZUC.

6. Structural studies of immunoglobulin G.

7. The covalent structure of an entire gammaG immunoglobulin molecule.

8. Structural studies of immunoglobulin G, M and A heavy chains.

9. Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups.

10. Molecular defect in a gamma-2 heavy chain.

Review 1. Progress in molecular and genetic studies of IgA nephropathy.

2. Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.

3. Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases.

Review 4. Biomarkers in IgA nephropathy: relationship to pathogenetic hits.

5. Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins.

Review 6. Involvement of Fc receptors in disorders of the central nervous system.

7. Localization of the cleavage site specificity determinant of Haemophilus influenzae immunoglobulin A1 protease genes.

Review 8. Glycosylation of IgA1 and pathogenesis of IgA nephropathy.

9. Protein Hal: partial deletion of a " " immunoglobulin gene(s) and apparent reinitiation at an internal AUG codon.

10. A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.