Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Enzymic depolymerization of macromolecular heparin as a factor in control of lipoprotein lipase activity.

Literature DB >> 4508335

Enzymic depolymerization of macromolecular heparin as a factor in control of lipoprotein lipase activity.

Abstract

Macromolecular heparin from rat skin shows poor lipoprotein lipase-releasing activity in vivo and is a potent inhibitor of rat-heart lipoprotein lipase in vitro. Rat-skin heparin is depolymerized by incubation with the 100,000 x g supernatant from a sonicated homogenate of rat small intestine. The depolymerized products, fractionated by gel filtration, range from inhibitors to activators of lipoprotein lipase as molecular size decreases. Depolymerized rat heparin in the same molecular size range as commercial heparin from pig intestinal mucosa has about two-thirds the activity of the commercial preparation, both in vivo and in vitro.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1972 PMID： 4508335 PMCID： PMC389795 DOI： 10.1073/pnas.69.11.3469

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

10 in total

1. A modified uronic acid carbazole reaction.

Authors: T BITTER; H M MUIR
Journal: Anal Biochem Date: 1962-10 Impact factor: 3.365

2. Inhibitory and activating effects of polyanions on lipoprotein lipase.

Authors: P BERNFELD; T F KELLEY
Journal: J Biol Chem Date: 1963-04 Impact factor: 5.157

3. Titration of free fatty acids of plasma: a study of current methods and a new modification.

Authors: D L TROUT; E H ESTES; S J FRIEDBERG
Journal: J Lipid Res Date: 1960-04 Impact factor: 5.922

4. Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart.

Authors: E D KORN
Journal: J Biol Chem Date: 1955-07 Impact factor: 5.157

5. A relation between non-esterified fatty acids in plasma and the metabolism of glucose.

Authors: V P DOLE
Journal: J Clin Invest Date: 1956-02 Impact factor: 14.808

6. ABOLISHMENT OF ALIMENTARY LIPEMIA FOLLOWING INJECTION OF HEPARIN.

Authors: P F Hahn
Journal: Science Date: 1943-07-02 Impact factor: 47.728

7. Electrophoretic separation of plasma lipoproteins in agarose gel.

Authors: R P Noble
Journal: J Lipid Res Date: 1968-11 Impact factor: 5.922

8. Macromolecular heparin from rat skin. Isolation, characterization, and depolymerization with ascorbate.

Authors: A A Horner
Journal: J Biol Chem Date: 1971-01-10 Impact factor: 5.157

9. The nature of two components of pig mucosal heparin, separated by electrophoresis in agarose gel.

Authors: A A Horner
Journal: Can J Biochem Date: 1967-07

10. The functional status of lipoprotein lipase in rat liver.

Authors: P A Mayes; J M Felts
Journal: Biochem J Date: 1968-07 Impact factor: 3.857

10 in total

8 in total

8. Rat heparins. A study of the relative sizes and antithrombin-binding characteristics of heparin proteoglycans, chains and depolymerization products from rat adipose tissue, heart, lungs, peritoneal cavity and skin.

Authors: A A Horner
Journal: Biochem J Date: 1986-11-15 Impact factor: 3.857

8 in total

Enzymic depolymerization of macromolecular heparin as a factor in control of lipoprotein lipase activity.

1. A modified uronic acid carbazole reaction.

2. Inhibitory and activating effects of polyanions on lipoprotein lipase.

3. Titration of free fatty acids of plasma: a study of current methods and a new modification.

4. Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart.

5. A relation between non-esterified fatty acids in plasma and the metabolism of glucose.

6. ABOLISHMENT OF ALIMENTARY LIPEMIA FOLLOWING INJECTION OF HEPARIN.

7. Electrophoretic separation of plasma lipoproteins in agarose gel.

8. Macromolecular heparin from rat skin. Isolation, characterization, and depolymerization with ascorbate.

9. The nature of two components of pig mucosal heparin, separated by electrophoresis in agarose gel.

10. The functional status of lipoprotein lipase in rat liver.

1. Crystallization of macromolecular heparin.

Review 2. Mechanism of the anticoagulant action of heparin.

3. The molecular-weight-dependence of the anti-coagulant activity of heparin.

4. The assay and partial characterization of macromolecular heparin depolymerase activity in rat small intestine.

5. Macromolecular properties and end-group analysis of heparin isolated from bovine liver capsule.

6. Metabolism of macromolecular heparin in mouse neoplastic mast cells.

7. Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder.

8. Rat heparins. A study of the relative sizes and antithrombin-binding characteristics of heparin proteoglycans, chains and depolymerization products from rat adipose tissue, heart, lungs, peritoneal cavity and skin.