Literature DB >> 4508318

Production of procollagen by human fibroblasts in culture.

B D Smith, P H Byers, G R Martin.   

Abstract

Three hydroxyproline-containing proteins secreted into the medium by human fibroblasts in culture were isolated and characterized. A minor fraction was identical to the collagen monomer. The major fraction was a form of procollagen, which contained, in addition to pro alpha and alpha chains, a component estimated to have a molecular weight of 250,000. This component was a dimer of pro alpha chains joined by disulfide bonds. The third fraction, much lower in hydroxyproline and hydroxylysine content, was of still greater size. Pro alpha chains were released upon denaturation and reduction, indicating that this fraction may contain pro alpha chains linked by disulfide bonds to noncollagenous material.

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Year:  1972        PMID： 4508318      PMCID： PMC389749          DOI： 10.1073/pnas.69.11.3260

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Inhibition of proline and lysine hydroxylation prevents normal extrusion of collagen by 3T6 fibroblasts in culture.

Authors:  P B. Ramaley; J Rosenbloom
Journal:  FEBS Lett       Date:  1971-06-02       Impact factor: 4.124

2.  Continuous scintillation counting of carbon-14 and tritium in effluent of the automatic amino acid analyzer.

Authors:  K A PIEZ
Journal:  Anal Biochem       Date:  1962-12       Impact factor: 3.365

3.  Collagen synthesis by cells II: secretion of a disulfide linked material.

Authors:  R E Burgeson; A W Wyke; J H Fessler
Journal:  Biochem Biophys Res Commun       Date:  1972-08-21       Impact factor: 3.575

4.  Studies on protocollagen: identification of a precursor of proto alpha 1.

Authors:  P K Müller; E McGoodwin; G R Martin
Journal:  Biochem Biophys Res Commun       Date:  1971-07-02       Impact factor: 3.575

5.  Collagen made of extended -chains, procollagen, in genetically-defective dermatosparaxic calves.

Authors:  A Lenaers; M Ansay; B V Nusgens; C M Lapière
Journal:  Eur J Biochem       Date:  1971-12-10

6.  Collagen synthesis on polysomes in vivo and in vitro.

Authors:  E Lazarides; L N Lukens
Journal:  Nat New Biol       Date:  1971-07-14

7.  Collagen biosynthesis: synthesis and secretion of a high molecular weight collagen precursor (procollagen).

Authors:  R L Church; S E Pfeiffer; M L Tanzer
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

8.  Biosynthesis of the alpha chains of collagen studied by pulse-labeling in culture.

Authors:  J Vuust; K A Piez
Journal:  J Biol Chem       Date:  1970-11-25       Impact factor: 5.157

9.  Evidence for procollagen, a biosynthetic precursors of collagen.

Authors:  G Bellamy; P Bornstein
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

10.  The nature of the collagen synthesized by cultured human fibroblasts.

Authors:  D L Layman; E B McGoodwin; G R Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205
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  30 in total

1.  Segment-long-spacing aggregates and isolation of COOH-terminal peptides from type I procollagen.

Authors:  H P Hoffmann; B R Olsen; H T Chen; D J Prockop
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

2.  Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain.

Authors:  P H Byers; E M Click; E Harper; P Bornstein
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

3.  Hexamethylene bisacetamide induces morphologic changes and increased synthesis of procollagen in cell line from glioblastoma multiforme.

Authors:  A S Rabson; R Stern; T S Tralka; J Costa; J Wilczek
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

4.  Inheritance of Ehlers-Danlos type IV syndrome.

Authors:  F M Pope; G R Martin; V A McKusick
Journal:  J Med Genet       Date:  1977-06       Impact factor: 6.318

5.  Characterization of the synthesized collagen by mouse L-929 (L-5) cells.

Authors:  S Matsubayashi; H Shinkai; S Sano
Journal:  Arch Dermatol Res       Date:  1977-10-27       Impact factor: 3.017

6.  Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum.

Authors:  R Halila; L Peltonen
Journal:  Biochem J       Date:  1986-10-01       Impact factor: 3.857

7.  Collagen studies in congenital cutis laxa.

Authors:  A Taïeb; M Aumailley; D Courouge-Dorcier; M Rabaud; P Bioulac-Sage; J E Surlève-Bazeille; J Maleville
Journal:  Arch Dermatol Res       Date:  1987       Impact factor: 3.017

8.  Biochemical and immunological studies of fibroblasts derived from a patient with Ehlers-Danlos syndrome type IV. Demonstrate reduced type III collagen synthesis.

Authors:  M Aumailley; T Krieg; W Dessau; P K Müller; R Timpl; H Bricaud
Journal:  Arch Dermatol Res       Date:  1980       Impact factor: 3.017

9.  Lung collagen heterogeneity.

Authors:  K Bradley; S McConnell-Breul; R G Crystal
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

10.  Lethal osteogenesis imperfecta congenita and a 300 base pair gene deletion for an alpha 1(I)-like collagen.

Authors:  F M Pope; K S Cheah; A C Nicholls; A B Price; F G Grosveld
Journal:  Br Med J (Clin Res Ed)       Date:  1984-02-11
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