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Literature DB >> 4506092

Calcium-dependent norepinephrine release from presynaptic nerve endings in vitro.

M P Blaustein, E M Johnson, P Needleman.

Abstract

Potassium concentrations above 15-20 mM in the medium, or addition of 75 muM veratridine to medium that contains 5 mM K, stimulate calcium accumulation and Ca-dependent norepinephrine release by presynaptic nerve terminals (synaptosomes) incubated in vitro. The effects of veratridine, but not of K, are blocked by 0.2 muM tetrodotoxin. This association between Ca entry and norepinephrine release is consistent with the Calcium Hypothesis of transmitter release. These results add further evidence that synaptosomes may retain many functional properties of intact presynaptic endings.

Entities: Chemical Gene

Mesh：

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Year: 1972 PMID： 4506092 PMCID： PMC426908 DOI： 10.1073/pnas.69.8.2237

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. A SENSITIVE METHOD FOR SPECTROPHOTOFLUOROMETRIC ASSAY OF CATECHOLAMINES.

Authors: C C CHANG
Journal: Int J Neuropharmacol Date: 1964-12

2. [Noradrenalin loss from the isolated rabbit heart following sympathetic nerve irritation and its pharmacological alteration].

Authors: S HUKOVIC; E MUSCHOLL
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1962

3. The subcellular localization of 5-hydroxytryptamine in guinea pig brain.

Authors: I A MICHAELSON; V P WHITTAKER
Journal: Biochem Pharmacol Date: 1963-02 Impact factor: 5.858

4. The role of calcium in the secretory response of the adrenal medulla to acetylcholine.

Authors: W W DOUGLAS; R P RUBIN
Journal: J Physiol Date: 1961-11 Impact factor: 5.182

5. The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors: E G GRAY; V P WHITTAKER
Journal: J Anat Date: 1962-01 Impact factor: 2.610

6. Batrachotoxin: chemistry and pharmacology.

Authors: E X Albuquerque; J W Daly; B Witkop
Journal: Science Date: 1971-06-04 Impact factor: 47.728

7. Metabolism of glucose and glutamate by synaptosomes from mammalian cerebral cortex.

Authors: H F Bradford; A J Thomas
Journal: J Neurochem Date: 1969-11 Impact factor: 5.372

8. The osmotically sensitive potassium and sodium compartments of synaptosomes.

Authors: R M Marchbanks
Journal: Biochem J Date: 1967-07 Impact factor: 3.857

9. Release of noradrenaline from the cat spleen by potassium.

Authors: S M Kirpekar; A R Wakade
Journal: J Physiol Date: 1968-02 Impact factor: 5.182

10. Release of noradrenaline by splenic nerve stimulation and its dependence on calcium.

Authors: S M Kirpekar; Y Misu
Journal: J Physiol Date: 1967-01 Impact factor: 5.182

35 in total

1. Inhibition of adrenergic neurotransmission in isolated veins of the dog by potassium ions.

Authors: R R Lorenz; P M Vanhoutte
Journal: J Physiol Date: 1975-03 Impact factor: 5.182

2. Proteins of the synaptic membrane.

Authors: H R Mahler
Journal: Neurochem Res Date: 1977-04 Impact factor: 3.996

3. Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

Authors: M P Blaustein
Journal: J Physiol Date: 1975-06 Impact factor: 5.182

Calcium-dependent norepinephrine release from presynaptic nerve endings in vitro.

1. A SENSITIVE METHOD FOR SPECTROPHOTOFLUOROMETRIC ASSAY OF CATECHOLAMINES.

2. [Noradrenalin loss from the isolated rabbit heart following sympathetic nerve irritation and its pharmacological alteration].

3. The subcellular localization of 5-hydroxytryptamine in guinea pig brain.

4. The role of calcium in the secretory response of the adrenal medulla to acetylcholine.

5. The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

6. Batrachotoxin: chemistry and pharmacology.

7. Metabolism of glucose and glutamate by synaptosomes from mammalian cerebral cortex.

8. The osmotically sensitive potassium and sodium compartments of synaptosomes.

9. Release of noradrenaline from the cat spleen by potassium.

10. Release of noradrenaline by splenic nerve stimulation and its dependence on calcium.

1. Inhibition of adrenergic neurotransmission in isolated veins of the dog by potassium ions.

2. Proteins of the synaptic membrane.

3. Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

4. Presynaptic receptor systems on the noradrenergic neurones of rat brain.

5. Release properties of isolated neuromuscular boutons of the garter snake.

6. Calcium uptake in preterminal central synapses: importance of mitochondria.

7. Inhibition by botulinum toxin of depolarization-evoked release of (14C)acetylcholine from synaptosomes in vitro.

8. Catecholamines release mediators in the opossum oesophageal circular smooth muscle.

9. Phosphorylation of specific, distinct proteins in synaptosomes and axons from squid nervous system.

10. The Bezold reflex: a special case of the left ventricular mechanoreceptor reflex.