Literature DB >> 4506088

Hemoglobin switching in sheep and goats: change in functional globin messenger RNA in reticulocytes and bone marrow cells.

A W Nienhuis, W F Anderson.   

Abstract

ANEMIA CAUSES A CHANGE IN THE TYPE OF CIRCULATING HEMOGLOBIN IN GOATS AND CERTAIN SHEEP: HbA (alpha(2)beta(2) (A)) is replaced by HbC (alpha(2)beta(2) (C)). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages in transition from beta(A) to beta(C) synthesis, active globin mRNA was isolated from bone marrow cells, as well as from reticulocytes. By assaying these globin mRNAs in a rabbit reticulocyte cell-free system, we have demonstrated that the switch from beta(A) to beta(C) globin synthesis is mediated via a change in functional globin mRNA.

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Year:  1972        PMID： 4506088      PMCID： PMC426896          DOI： 10.1073/pnas.69.8.2184

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Cell-free hemoglobin synthesis. II. Characteristics of the transfer ribonucleic acid-dependent assay system.

Authors:  J M Gilbert; W F Anderson
Journal:  J Biol Chem       Date:  1970-05-10       Impact factor: 5.157

2.  The production of haemoglobin C in adult sheep and goats.

Authors:  M H Blunt; T H Huisman; J P Lewis
Journal:  Aust J Exp Biol Med Sci       Date:  1969-10

3.  Erythropoietic kinetics in sheep studied by means of induced changes in hemoglobin phenotype.

Authors:  T G Gabuzda; M A Schuman; R K Silver; H B Lewis
Journal:  J Clin Invest       Date:  1968-08       Impact factor: 14.808

4.  Reagents which reduce interactions between ribosomal RNA and rapidly labelled RNA from rat liver.

Authors:  J H Parish; K S Kirby
Journal:  Biochim Biophys Acta       Date:  1966-12-21

5.  On the mechanism of erythropoietin-induced differentiation. V. Characterization of the ribonucleic acid formed as a result of erythropoietin action.

Authors:  M Gross; E Goldwasser
Journal:  Biochemistry       Date:  1969-05       Impact factor: 3.162

6.  Hemoglobin C in newborn sheep and goats: a possible explanation for its function and biosynthesis.

Authors:  T H Huisman; J P Lewis; M H Blunt; H R Adams; A Miller; A M Dozy; E M Boyd
Journal:  Pediatr Res       Date:  1969-05       Impact factor: 3.756

7.  Hemoglobin messenger ribonucleic acid. Synthesis of 9S and ribosomal ribonucleic acid during erythroid cell development.

Authors:  M J Evans; J B Lingrel
Journal:  Biochemistry       Date:  1969-07       Impact factor: 3.162

8.  Hemoglobins in sheep: multiple differences in amino acid sequences of three beta-chains and possible origins.

Authors:  S H Boyer; P Hathaway; F Pascasio; C Orton; J Bordley; M A Naughton
Journal:  Science       Date:  1966-09-23       Impact factor: 47.728

9.  Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeak and hb J (Bangkok).

Authors:  J B Clegg; M A Naughton; D J Weatherball
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

10.  An improved method for radioautography of erythropoietic cells labeled with Fe 55 or Fe 59.

Authors:  J H Fowler; E A McCulloch; J E Till; L Siminovitch
Journal:  J Lab Clin Med       Date:  1966-09
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  9 in total

Review 1.  Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.

Authors:  Andrew Wilber; Arthur W Nienhuis; Derek A Persons
Journal:  Blood       Date:  2011-02-14       Impact factor: 22.113

2.  Hemoglobin switching in sheep and goats: induction of hemoglobin C synthesis in cultures of sheep fetal erythroid cells.

Authors:  J E Barker; J E Pierce; B C Kefauver; A W Nienhuis
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

Review 3.  Recent developments in foetal haemoglobin research.

Authors:  H Kamuzora
Journal:  Humangenetik       Date:  1975-09-20

4.  Hemoglobin messenger RNA from human bone marrow. Isolation and translation in homozygous and heterozygous beta-thalassemia.

Authors:  A W Nienhuis; P H Canfield; W F Anderson
Journal:  J Clin Invest       Date:  1973-07       Impact factor: 14.808

5.  Hemogloblin switching in sheep and goats: erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures.

Authors:  J E Barker; J A Last; S L Adams; A W Nienhuis; W F Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

6.  Unequal accumulation of alpha- and beta-globin mRNA in erythropoietic mouse spleen.

Authors:  T C Cheng; H H Kazazian
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

7.  Three mouse models of human thalassemia.

Authors:  J Martinell; J B Whitney; R A Popp; L B Russell; W F Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

8.  Hemoglobin synthesis in somatic cell hybrids: coexpression of mouse with human or chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells.

Authors:  A Deisseroth; J Barker; W F Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

9.  Hemoglobin switching in sheep and goats. V. Effect of erythropoietin concentration on in vitro erythroid colony growth and globin synthesis.

Authors:  J E Barker; W F Anderson; A W Nienhuis
Journal:  J Cell Biol       Date:  1975-03       Impact factor: 10.539
  9 in total

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