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Literature DB >> 4506081

Blocking by histones of accessibility to DNA in chromatin.

Abstract

The effect of histones on accessibility of DNA to DNase in chromatin of thymus nuclei has been studied by selective extraction of either lysine-rich or arginine-rich histones. It was found that all histones block accessibility but that, weight for weight, lysine-rich histones block much more effectively than do arginine-rich histones. We point to the contrast between accessibility of DNA to DNase and of DNA to RNA polymerase, and to what may be the similarity between accessibility to DNase and DNA polymerase.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 4506081 PMCID： PMC426880 DOI： 10.1073/pnas.69.8.2115

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

1. The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes.

Authors: A E Mirsky; C J Burdick; E H Davidson; V C Littau
Journal: Proc Natl Acad Sci U S A Date: 1968-10 Impact factor: 11.205

2. Studies on the role of histones in the structure of chromatin.

Authors: J E Smart; J Bonner
Journal: J Mol Biol Date: 1971-06-28 Impact factor: 5.469

3. Proteins of chromatin in template restriction. II. Specificity of RNA synthesis.

Authors: T C Spelsberg; L S Hnilica
Journal: Biochim Biophys Acta Date: 1971-01-01

4. Proteins of chromatin in template restriction. I. RNA synthesis in vitro.

Authors: T C Spelsberg; L S Hnilica
Journal: Biochim Biophys Acta Date: 1971-01-01

5. Effects of low salt concentration on structural organization and template activity of chromatin in chicken erythrocyte nuclei.

Authors: K Brasch; V L Seligy; G Setterfield
Journal: Exp Cell Res Date: 1971-03 Impact factor: 3.905

6. High resolution acrylamide gel electrophoresis of histones.

Authors: S Panyim; R Chalkley
Journal: Arch Biochem Biophys Date: 1969-03 Impact factor: 4.013

7. The role of histones in the maintenance of chromatin structure.

Authors: V C Littau; C J Burdick; V G Allfrey; S A Mirsky
Journal: Proc Natl Acad Sci U S A Date: 1965-10 Impact factor: 11.205

8. The isolation, properties, and possible functions of chromatin acidic proteins.

Authors: T Y Wang
Journal: J Biol Chem Date: 1967-03-25 Impact factor: 5.157

9. Nucleohistone as template for the replication of DNA.

Authors: S Schwimmer; J Bonner
Journal: Biochim Biophys Acta Date: 1965-09-06

10. Stepwise removal of protein from a deoxyribonucleoprotein complex and de-repression of the genome.

Authors: G P Georgiev; L N Ananieva; J V Kozlov
Journal: J Mol Biol Date: 1966-12-28 Impact factor: 5.469

12 in total

1. Isolation and physicochemical characterisation of the DNA from normal human skin and psoriatic scales.

Authors: G Teimer; G Ramb; G Leonhardi
Journal: Arch Dermatol Res Date: 1976-10-27 Impact factor: 3.017

2. Accessibility of DNA in chromatin to DNA polymerase and RNA polymerase.

Authors: B Silverman; A E Mirsky
Journal: Proc Natl Acad Sci U S A Date: 1973-05 Impact factor: 11.205

3. Mammalian chromatin substructure studies with the calcium-magnesium endonuclease and two-dimensional polyacrylamide-gel electrophoresis.

Authors: L A Burgoyne; D R Hewish; J Mobbs
Journal: Biochem J Date: 1974-10 Impact factor: 3.857

10. Effects of selective extraction of histones on template activities of chromatin by use of exogenous DNA and RNA polymerases.

Authors: A E Mirsky; B Silverman
Journal: Proc Natl Acad Sci U S A Date: 1973-07 Impact factor: 11.205