Literature DB >> 4505652

Diphenylhydantoin inhibition of sodium conductance in squid giant axon.

R J Lipicky, D L Gilbert, I M Stillman.   

Abstract

Diphenylhydantoin, in concentration of 5-50 muM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.

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Year:  1972        PMID： 4505652      PMCID： PMC426796          DOI： 10.1073/pnas.69.7.1758

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

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7.  Drug effects on the spontaneous electrical activity of the squid giant axon.

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Journal:  J Gen Physiol       Date:  1967-05       Impact factor: 4.086
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  11 in total

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5.  Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin.

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6.  Ineffectiveness of adrenocorticosteroids and adrenocorticotropin in altering Na-K currents in squid giant axon.

Authors:  R I Henkin; D L Gilbert; I Stillman; R DiPolo
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9.  Effects of some antiepileptic drugs on the repetitive activity of the node of Ranvier.

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