| Literature DB >> 4504358 |
Abstract
An L-cell line adapted to grow in protein-free medium is a source of material that stimulates the proliferation of serum-dependent BHK cells under otherwise protein-free conditions. The material produced by the L-cells is resolvable into separate DNA-synthetic and mitotic stimulatory activities. The stimulation of mitosis is dependent upon the presence of one or more heat-labile macromolecules, which can be concentrated by ultrafiltration, and at least one dialyzable component is essential for the initiation of DNA synthesis.Mesh:
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Year: 1972 PMID: 4504358 PMCID: PMC426724 DOI: 10.1073/pnas.69.6.1455
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205