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Literature DB >> 4504332

On the mechanism of action of vitamin B 12 . Model studies. Thermal rearrangement of methyl 3,3-dimethylglycidate to methyl levulinate.

Abstract

The discovery that methyl 3,3-dimethylglycidate rearranges to methyl levulinate on heating is discussed in terms of its possible consequences for the mechanism of action of the coenzyme B(12)-dependent enzymes: methylmalonyl-CoA mutase (EC 5.4.99.2), glutamate mutase (EC 5.4.99.1), and a-methyleneglutarate mutase. It is also suggested that the proposed mechanism may provide a unifying link between the mechanism of action of the above enzymes and that of the coenzyme B(12)-dependent dioldehydrase and related enzymes.

Entities: Chemical Gene

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Year: 1972 PMID： 4504332 PMCID： PMC426656 DOI： 10.1073/pnas.69.5.1173

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. METHYLMALONYL ISOMERASE, II. PURIFICATION AND PROPERTIES OF THE ENZYME FROM PROPIONIBACTERIA.

Authors: R Stjernholm; H G Wood
Journal: Proc Natl Acad Sci U S A Date: 1961-03 Impact factor: 11.205

2. A COENZYME CONTAINING PSEUDOVITAMIN B(12).

Authors: H A Barker; H Weissbach; R D Smyth
Journal: Proc Natl Acad Sci U S A Date: 1958-11-15 Impact factor: 11.205

3. Nicotinic acid metabolism. VII. Mechanisms of action of clostridial -methyleneglutarate mutase (B 12 -dependent) and methylitaconate isomerase.

Authors: H Kung; L Tsai
Journal: J Biol Chem Date: 1971-11 Impact factor: 5.157

4. Studies on the mechanism of hydrogen transfer in the coenzyme B12 dependent dioldehydrase reaction II.

Authors: M K Essenberg; P A Frey; R H Abeles
Journal: J Am Chem Soc Date: 1971-03-10 Impact factor: 15.419

5. Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase.

Authors: H F Kung; T C Stadtman
Journal: J Biol Chem Date: 1971-05-25 Impact factor: 5.157

6. Mechanism of action of coenzyme B 12 . Hydrogen transfer in the isomerization of -methylaspartate to glutamate.

Authors: R G Eagar; M M Herbst; H A Barker; J H Richards
Journal: Biochemistry Date: 1972-01-18 Impact factor: 3.162

7. The role of the B12 coenzyme in the conversion of 1,2-propanediol to propionaldehyde.

Authors: P A Frey; R H Abeles
Journal: J Biol Chem Date: 1966-06-10 Impact factor: 5.157

8. The nature of the hydrogen transfer in the dimethylbenzimidazolylcobamide coenzyme-catalyzed conversion of 1,2-propanediol to propionaldehyde.

Authors: R H Abeles; B Zagalak
Journal: J Biol Chem Date: 1966-03-10 Impact factor: 5.157