Literature DB >> 450390

Effect of 1(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on Sato lung carcinoma (SLC). Preliminary result of immunochemotherapy for SLC by combination of ACNU and Propionibacterium acnes.

N Saijo, H Niitani, N Irimajiri, M Chikama.   

Abstract

ACNU was highly effective for Sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of ACNU for SLC showed clear dependence upon tumor size. Nonspecific activation of host-defence mechanism by Propionibacterium acnes contributed to the suppression for the regrowth of solid SLC treated by ACNU.

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Year:  1979        PMID： 450390     DOI： 10.1159/000225309

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  3 in total

1.  Experimental and clinical effect of ACNU in Japan with emphasis on small-cell carcinoma of the lung.

Authors:  N Saijo; H Niitani
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

Review 2.  Highlights for ESMO 40: celebration review for lifetime achievement awards.

Authors:  Nagahiro Saijo
Journal:  ESMO Open       Date:  2016-02-17

3.  Effects of BCG and 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on the cytostatic activity of macrophages in normal and tumour-bearing rats.

Authors:  N Saijo; N Irimajiri; A Ozaki; E Shimizu; H Niitani
Journal:  Br J Cancer       Date:  1980-07       Impact factor: 7.640
  3 in total

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