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Literature DB >> 4501587

Electromechanochemical model of mitochondrial structure and function.

Abstract

A NEW MODEL OF MITOCHONDRIAL STRUCTURE AND FUNCTION IS PROPOSED ON THE BASIS OF FOUR FUNDAMENTAL ASSUMPTIONS: (a) electrons and protons are separated in the electron transfer complexes; (b) the ATPase undergoes conformational state-transitions induced by an electric field; (c) energy is transferred by an electric field effect; and (d) a conformationally strained protein system can be relaxed via a bond-forming chemical reaction. The model can explain all of the mitochondrial coupled processes and, in addition, it provides a reasonable rationalization of the correlation between mitochondrial structure and function.

Entities: Disease Gene

Mesh：

Substances：
Potassium

Year: 1972 PMID： 4501587 PMCID： PMC426544 DOI： 10.1073/pnas.69.3.726

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

8 in total

1. Active transport of inorganic phosphate and magnesium ions by beef heart mitochondria.

Authors: G P BRIERLEY; E BACHMANN; D E GREEN
Journal: Proc Natl Acad Sci U S A Date: 1962-11-15 Impact factor: 11.205

2. Partial resolution of the enzymes catalyzing oxidative phosphorylation. X. Correlation of morphology and function in submitochondrial particles.

Authors: Y Kagawa; E Racker
Journal: J Biol Chem Date: 1966-05-25 Impact factor: 5.157

3. Conformational basis of energy transformations in membrane systems. 3. Configurational changes in the mitochondrial inner membrane induced by changes in functional states.

Authors: D E Green; J Asai; R A Harris; J T Penniston
Journal: Arch Biochem Biophys Date: 1968-05 Impact factor: 4.013

5 in total

Electromechanochemical model of mitochondrial structure and function.

1. Active transport of inorganic phosphate and magnesium ions by beef heart mitochondria.

2. Partial resolution of the enzymes catalyzing oxidative phosphorylation. X. Correlation of morphology and function in submitochondrial particles.

3. Conformational basis of energy transformations in membrane systems. 3. Configurational changes in the mitochondrial inner membrane induced by changes in functional states.

4. Energy transduction in membrane systems.

5. The relation of respiration-dependent proton transfer to mitochondrial structure.

6. The conformational basis of energy transformations in membrane systems. I. Conformational changes in mitochondria.

7. A mechanism for the reactions of calcium with mitochondria.

8. The isolation and properties of a peptide ionophore from beef heart mitochondria.

1. On the meaning of effects of substrate structure on biological transport.

2. Removal of lipid from intact erythrocytes and ghosts by aqueous solutions and its relevance to membrane structure.

3. Structure-function unitization model of biological membranes.

4. Piezoelectric theory of enzymic catalysis as inferred from the electromechanochemical principles of bioenergetics.

5. Transductional and structural principles of the mitochondrial transducing unit.