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Literature DB >> 4500542

Selective condensation of aminoacyl adenylates by nucleoproteinoid microparticles (prebiotic-lysine-model system-genetic code).

Abstract

Microparticles composed of each of four enzymically synthesized homopolynucleotides and the same lysine-rich proteinoid have been found to influence the condensation of the AMP-anhydrides of each of four amino acids. The conditions of preparation of the particles and other variables of the experiments control the types of reaction. When a specified set of conditions was identified empirically, the incorporation favored the amino acids whose present-day codons are related to the homopolynucleotide in the particle.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 4500542 PMCID： PMC427555 DOI： 10.1073/pnas.69.1.106

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

6 in total

6. Selective formation of particles by binding of pyrimidine polyribonucleotides or purine polyribonucleotides with lysine-rich or arginine-rich proteinoids.

Authors: A Yuki; S W Fox
Journal: Biochem Biophys Res Commun Date: 1969-08-15 Impact factor: 3.575

6 in total

21 in total

9. From proteinoid microsphere to contemporary cell: formation of internucleotide and peptide bonds by proteinoid particles.

Authors: S W Fox; J R Jungck; T Nakashima
Journal: Orig Life Date: 1974 Jan-Apr

10. Synthesis of oligonucleotides by proteinoid microspheres acting on ATP.

Authors: J R Jungck; S W Fox
Journal: Naturwissenschaften Date: 1973-09

Selective condensation of aminoacyl adenylates by nucleoproteinoid microparticles (prebiotic-lysine-model system-genetic code).

1. The chemical synthesis of amino acyladenylates.

2. Self-ordered polymers and propagative cell-like systems.

3. The binding of basic proteinoids with organismic or thermally synthesized polynucleotides.

4. The thermal synthesis of neutral and basic proteinoids.

5. The condensation of the adenylates of the amino acids common to protein.

6. Selective formation of particles by binding of pyrimidine polyribonucleotides or purine polyribonucleotides with lysine-rich or arginine-rich proteinoids.

1. A model for the coevolution of the genetic code and the process of protein synthesis: Review and assessment.

2. Response to comments on thermal polypeptides by P. A. Temussi et al.

3. Aminoacyl transfer from an adenylate anhydride to polyribonucleotides.

Review 4. Origins of biological information and the genetic code.

Review 5. Chemical evolution. Recent syntheses of bioorganic molecules.

6. Stereospecificity of the genetic code.

7. Origin of the genetic code: a physical-chemical model of primitive codon assignments.

8. Origin of the cell: experiments and premises.

9. From proteinoid microsphere to contemporary cell: formation of internucleotide and peptide bonds by proteinoid particles.

10. Synthesis of oligonucleotides by proteinoid microspheres acting on ATP.