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Literature DB >> 448797

Origin of small RNA in von Magnus particles of influenza virus.

Abstract

A clone of recombinant virus obtained from the cross between WSN and Hong Kong strains of influenza virus gave rise to progeny containing predominantly von Magnus particles. In the electropherogram of virus RNA, the P3 gene was markedly diminished, and a new species of RNA (extra RNA) was present in addition to eight gene segments. The origin of the extra RNA was studied by two-dimensional gel electrophoresis of T1 RNase-generated oligonucleotides. Four out of five large oligonucleotide spots present in the extra RNA matched to those contained by the P3 gene. It was concluded that the extra RNA was derived from the P3 gene probably by deletion. The possible origin of the spot which was present in the extra RNA but not in eight gene segments including P3 was discussed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1979 PMID： 448797 PMCID： PMC353274

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Incomplete forms of influenza virus.

Authors: P VON MAGNUS
Journal: Adv Virus Res Date: 1954 Impact factor: 9.937

Review 2. Viral pathogenesis and molecular biology.

Authors: A S Huang
Journal: Bacteriol Rev Date: 1977-12

3. Studies on the generation of vesicular stomatitis virus (indiana serotype) defective interfering particles.

Authors: C Y Kang; T Glimp; J P Clewley; D H Bishop
Journal: Virology Date: 1978-01 Impact factor: 3.616

4. Mapping of the influenza virus genome. II. Identification of the P1, P2, and P3 genes.

Authors: P Palese; M B Ritchey; J L Schulman
Journal: Virology Date: 1977-01 Impact factor: 3.616

5. The generation and propagation of defective-interfering particles of Semliki Forest virus in different cell types.

Authors: C Stark; S I Kennedy
Journal: Virology Date: 1978-08 Impact factor: 3.616

6. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950.

Authors: K Nakajima; U Desselberger; P Palese
Journal: Nature Date: 1978-07-27 Impact factor: 49.962

7. Homologous interference mediated by defective interfering influenza virus derived from a temperature-sensitive mutant of influenza virus.

Authors: D P Nayak; K Tobita; J M Janda; A R Davis; B K De
Journal: J Virol Date: 1978-10 Impact factor: 5.103

8. Identification of hemagglutinin and neuraminidase genes of influenza B virus.

Authors: M Ueda; K Tobita; A Sugiura; C Enomoto
Journal: J Virol Date: 1978-02 Impact factor: 5.103

9. Mapping of the influenza virus genome. III. Identification of genes coding for nucleoprotein, membrane protein, and nonstructural protein.

Authors: M B Ritchey; P Palese; J L Schulman
Journal: J Virol Date: 1976-10 Impact factor: 5.103

10. Biochemical evidence that "new" influenza virus strains in nature may arise by recombination (reassortment).

Authors: U Desselberger; K Nakajima; P Alfino; F S Pedersen; W A Haseltine; C Hannoun; P Palese
Journal: Proc Natl Acad Sci U S A Date: 1978-07 Impact factor: 11.205

23 in total

1. Specific residues of the influenza A virus hemagglutinin viral RNA are important for efficient packaging into budding virions.

Authors: Glenn A Marsh; Raheleh Hatami; Peter Palese
Journal: J Virol Date: 2007-07-18 Impact factor: 5.103

2. Segment-specific noncoding sequences of the influenza virus genome RNA are involved in the specific competition between defective interfering RNA and its progenitor RNA segment at the virion assembly step.

Authors: T Odagiri; M Tashiro
Journal: J Virol Date: 1997-03 Impact factor: 5.103

Review 3. Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?

Authors: Nigel J Dimmock; Andrew J Easton
Journal: J Virol Date: 2014-02-26 Impact factor: 5.103

Origin of small RNA in von Magnus particles of influenza virus.

1. Incomplete forms of influenza virus.

Review 2. Viral pathogenesis and molecular biology.

3. Studies on the generation of vesicular stomatitis virus (indiana serotype) defective interfering particles.

4. Mapping of the influenza virus genome. II. Identification of the P1, P2, and P3 genes.

5. The generation and propagation of defective-interfering particles of Semliki Forest virus in different cell types.

6. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950.

7. Homologous interference mediated by defective interfering influenza virus derived from a temperature-sensitive mutant of influenza virus.

8. Identification of hemagglutinin and neuraminidase genes of influenza B virus.

9. Mapping of the influenza virus genome. III. Identification of genes coding for nucleoprotein, membrane protein, and nonstructural protein.

10. Biochemical evidence that "new" influenza virus strains in nature may arise by recombination (reassortment).

1. Specific residues of the influenza A virus hemagglutinin viral RNA are important for efficient packaging into budding virions.

2. Segment-specific noncoding sequences of the influenza virus genome RNA are involved in the specific competition between defective interfering RNA and its progenitor RNA segment at the virion assembly step.

Review 3. Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?

4. Sequence relationships among defective interfering influenza viral RNAs.

5. Isolation of a novel type of interfering influenza B virus defective in the function of M gene.

6. Expression of defective-interfering influenza virus-specific transcripts and polypeptides in infected cells.

7. Incomplete avian influenza virus contains a defective non-interfering component.

8. Extra RNAs of von Magnus particles of influenza virus cause reduction of particular polymerase genes.

9. Evidence for segment-nonspecific packaging of the influenza a virus genome.

Review 10. Influenza virus morphogenesis and budding.