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Literature DB >> 4480288

Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain.

Abstract

1 Benzoctamine, a new psychoactive drug, known to exert in man an anti-anxiety effect resembling that of chlordiazepoxide, decreased the disappearance of intraventricularly-injected [(14)C]-5-hydroxytryptamine (5-HT) from rat brain, as did chlordiazepoxide.2 Both drugs partially inhibited the alpha-ethyl-3-hydroxy-4-methylphenylethylamine-induced depletion of rat brain 5-HT.3 It is concluded that benzoctamine, like chlordiazepoxide, decreases 5-HT turnover in the brain and that this action may play a role in the anti-anxiety effect of these drugs observed in man.

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Year: 1974 PMID： 4480288 PMCID： PMC1778070 DOI： 10.1111/j.1476-5381.1974.tb09676.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

23 in total

1. The importance of the nervous impulse flow for the depletion of the monoamines from central neurones by some drugs.

Authors: N E Andén; F Fuxe; T Hökfelt
Journal: J Pharm Pharmacol Date: 1966-09 Impact factor: 3.765

2. Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine.

Authors: A Carlsson; H Corrodi; K Fuxe; T Hökfelt
Journal: Eur J Pharmacol Date: 1969-03 Impact factor: 4.432

3. A method for the determination of serotonin and norepinephrine in discrete areas of rat brain.

Authors: R P Maickel; R H Cox; J Saillant; F P Miller
Journal: Int J Neuropharmacol Date: 1968-05

4. Effects of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain.

Authors: J J Schildkraut; S M Schanberg; G R Breese; I J Kopin
Journal: Biochem Pharmacol Date: 1969-08 Impact factor: 5.858

5. Localization of tritiated serotonin in rat brain by electron-microscopic autoradiography.

Authors: G K Aghajanian; F E Bloom
Journal: J Pharmacol Exp Ther Date: 1967-04 Impact factor: 4.030

6. Uptake and metabolism of [14C] serotonin in rat brain.

Authors: D Palaić; I H Page; P A Khairallah
Journal: J Neurochem Date: 1967-01 Impact factor: 5.372

7. A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.

Authors: E P Noble; R J Wurtman; J Axelrod
Journal: Life Sci Date: 1967-02-01 Impact factor: 5.037

8. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

Authors: J Glowinski; L L Iversen
Journal: J Neurochem Date: 1966-08 Impact factor: 5.372

9. Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide.

Authors: N E Andén; H Corrodi; K Fuxe; T Hökfelt
Journal: Br J Pharmacol Date: 1968-09 Impact factor: 8.739

10. Studies on uptake of intraventricularly administered tritiated noradrenaline and 5-hydoxytryptamine with combined fluorescence histochemical and autoradiographic technics.

Authors: K Fuxe; T Hökfelt; M Ritzén; U Ungerstedt
Journal: Histochemie Date: 1968

5 in total

Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain.

1. The importance of the nervous impulse flow for the depletion of the monoamines from central neurones by some drugs.

2. Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine.

3. A method for the determination of serotonin and norepinephrine in discrete areas of rat brain.

4. Effects of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain.

5. Localization of tritiated serotonin in rat brain by electron-microscopic autoradiography.

6. Uptake and metabolism of [14C] serotonin in rat brain.

7. A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.

8. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

9. Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide.

10. Studies on uptake of intraventricularly administered tritiated noradrenaline and 5-hydoxytryptamine with combined fluorescence histochemical and autoradiographic technics.

1. Benzodiazepines: specific competitors for the binding of L-tryptophan to human serum albumin.

2. Chlordiazepoxide loses its anxiolytic action with long-term treatment.

3. Effects of pyrroxan and chlordiazepoxide on biogenic amine metabolism in the rat brain.

4. Effect of benzodiazepines on central serotonergic neuron systems.

5. Lack of central 5-hydroxytryptamine influence on the anticonflict activity of diazepam.