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Literature DB >> 4478801

Concentrations of histamine in brain of guinea pig and rat during dietary protein malnutrition.

Abstract

Protein malnutrition produced marked elevations in brain contents of histamine in guinea pigs (+142%) and rats (+257%) in comparison with findings in the control adequately fed animals. Associated with accumulation of this biogenic amine in each set of animals was an increase of similar magnitude in brain content of free histidine. It was concluded that the elevated brain content of histamine in protein malnutrition was due mainly to increased availability of the precursor amino acid, and that such alterations in amounts of neurotransmitter amines in the central nervous system might underlie some of the behavioural abnormalities seen in malnourished animals.

Entities: Chemical Disease Species

Mesh：

Substances：
Histidine
Histamine

Year: 1974 PMID： 4478801 PMCID： PMC1168540 DOI： 10.1042/bj1440601

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

32 in total

1. Alterations in ninhydrin-positive substances and cytoplasmic protein synthesis in the brains of ascorbic acid-deficient guinea pigs.

Authors: C O Enwonwu
Journal: J Neurochem Date: 1973-07 Impact factor: 5.372

5. Studies of hepatic lesions of experimental protein-calorie malnutrition in rats and immediate effects of refeeding an adequate protein diet.

Authors: C O Enwonwu; L M Sreebny
Journal: J Nutr Date: 1971-04 Impact factor: 4.798

1. Rapid development of oedema and defective brain histidine metabolism in young guinea pigs fed protein-energy deficient diet.

Authors: C O Enwonwu; G O Okadigbo
Journal: Br J Exp Pathol Date: 1983-10

1 in total

Concentrations of histamine in brain of guinea pig and rat during dietary protein malnutrition.

1. Alterations in ninhydrin-positive substances and cytoplasmic protein synthesis in the brains of ascorbic acid-deficient guinea pigs.

2. Nutrition and the brain.

3. Histamine: a stimulatory effect on drinking behavior in the rat.

4. Nutrition and man's intellect and behavior.

5. Studies of hepatic lesions of experimental protein-calorie malnutrition in rats and immediate effects of refeeding an adequate protein diet.

6. Histamine and metabolites: their effects and interactions with convulsants on brain stem neurones.

7. Alterations in cerebral protein metabolism in the progeny of protein-calorie-deficient rats.

8. Histamine and spermidine content in brain during development.

9. Circadian rhythms in rat mid-brain and caudate nucleus biogenic amine levels.

10. Brain catechol synthesis: control by train tyrosine concentration.

1. Rapid development of oedema and defective brain histidine metabolism in young guinea pigs fed protein-energy deficient diet.