Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Urinary excretion of diphenylhydantoin metabolites in newborn infants.

Literature DB >> 4475101

Urinary excretion of diphenylhydantoin metabolites in newborn infants.

Abstract

The plasma half-life of diphenylhydantoin newborn infants of epileptic mothers, treated with this drug, is in the same range as the plasma half-life in adults. The urinary excretion of diphenylydantoin and its main metabolites has been investigated in six newborn infants. The results show that the rapid plasma disappearance of diphenylhydantoin is due to rapid metabolism of the drug.

Entities: Chemical Disease Species

Mesh：

Substances：
Phenytoin

Year: 1974 PMID： 4475101 DOI： 10.1016/s0022-3476(74)80466-x

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

Keyword Cloud
Cited

12 in total

1. Pharmacokinetic observations of phenytoin disposition in the newborn and young infant.

Authors: P M Loughnan; A Greenwald; W W Purton; J V Aranda; G Watters; A H Neims
Journal: Arch Dis Child Date: 1977-04 Impact factor: 3.791

Review 2. Clinical pharmacology of the perinatal period and early infancy.

Authors: P L Morselli
Journal: Clin Pharmacokinet Date: 1989 Impact factor: 6.447

Review 3. Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II).

Authors: J B Besunder; M D Reed; J L Blumer
Journal: Clin Pharmacokinet Date: 1988-05 Impact factor: 6.447

Review 4. Drug kinetics in pregnancy.

Authors: B Krauer; F Krauer
Journal: Clin Pharmacokinet Date: 1977 May-Jun Impact factor: 6.447

Urinary excretion of diphenylhydantoin metabolites in newborn infants.

1. Pharmacokinetic observations of phenytoin disposition in the newborn and young infant.

Review 2. Clinical pharmacology of the perinatal period and early infancy.

Review 3. Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II).

Review 4. Drug kinetics in pregnancy.

Review 5. Anticonvulsants during pregnancy and lactation. Transplacental, maternal and neonatal pharmacokinetics.

6. Anticonvulsants in the newborn period.

7. Kinetics of placentally transferred phenytoin and its p-hydroxylated metabolites in newborn infants.

8. Assay of the major (4-hydroxylated) metabolites of diphenylhydantoin in human urine.

9. A study of conjugation and drug elimination in the human neonate.

10. Carbamazepine and its 10,11-epoxide in children and adults with epilepsy.