Literature DB >> 4469692

Ethanol inhibition of vitamin A metabolism in the testes: possible mechanism for sterility in alcoholics.

D H Van Thiel, J Gavaler, R Lester.   

Abstract

Vitanin A (retinol) is essential for spermatogenesis. Alcohol dehydrogenase, the enzyme responsible for ethanol metabolism, is also required for the conversion of retinol to bioactive retinal at the end organ site. Ethanol inhibits the oxidation of retinol by testicular homogenates containing alcohol dehydrogenase. Thus, a possible biochemnical mechanism for the sterility of chronic alcoholics is identified.

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Year:  1974        PMID： 4469692     DOI： 10.1126/science.186.4167.941

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  Electroretinographic examination and definition of serum zinc levels in patients with chronic pancreatitis.

Authors:  T Riesz; L Anda; M Arató; K Róna; A Fenyvesi; N Hudomel
Journal:  Gastroenterol Jpn       Date:  1987-02

Review 2.  Effects of ethanol on physiological retinoic acid levels.

Authors:  Joseph L Napoli
Journal:  IUBMB Life       Date:  2011-07-15       Impact factor: 3.885

3.  Normal testicular structure and reproductive function in deermice lacking retinol and alcohol dehydrogenase activity.

Authors:  M A Leo; C S Lieber
Journal:  J Clin Invest       Date:  1984-02       Impact factor: 14.808

4.  Liver disease in the alcoholic.

Authors:  A Szilagyi
Journal:  Can Fam Physician       Date:  1986-09       Impact factor: 3.275

Review 5.  Functions of Intracellular Retinoid Binding-Proteins.

Authors:  Joseph L Napoli
Journal:  Subcell Biochem       Date:  2016

6.  Mechanism of hypogonadism in cirrhotic males.

Authors:  G R Green
Journal:  Gut       Date:  1977-10       Impact factor: 23.059

Review 7.  Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage.

Authors:  J R West; W J Chen; N J Pantazis
Journal:  Metab Brain Dis       Date:  1994-12       Impact factor: 3.584

8.  Inhibition of testosterone biosynthesis by ethanol. Relation to hepatic and testicular acetaldehyde, ketone bodies and cytosolic redox state in rats.

Authors:  C J Eriksson; T V Widenius; R H Ylikahri; M Härkönen; P Leinonen
Journal:  Biochem J       Date:  1983-01-15       Impact factor: 3.857

9.  Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis.

Authors:  G Duester; M L Shean; M S McBride; M J Stewart
Journal:  Mol Cell Biol       Date:  1991-03       Impact factor: 4.272

Review 10.  The adverse effects of alcohol on vitamin A metabolism.

Authors:  Robin D Clugston; William S Blaner
Journal:  Nutrients       Date:  2012-05-07       Impact factor: 5.717
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