Literature DB >> 446681

Inhibitory effect of cytokinins on PHA-induced human lymphocyte stimulation.

T Saito, Y Shibata, T Kurokawa, N Ishida.   

Abstract

The inhibitory effect of various purine derivatives on PHA-induced human lymphocyte blast formation was studied. Two nucleoside cytokinins, N6-benzyladenosine and N6-isopentenyladenosine, inhibited blast formation at concentrations as low as 10(-6) M. However, the other cytokinins, which lacked the ribosyl residue at N9 position, had to be at the higher molar concentration of 10(-4) before they could induce the same inhibitory effect.

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Year:  1979        PMID: 446681     DOI: 10.1007/bf01960399

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  7 in total

1.  Inhibition of PHA-induced lymphocyte stimulation by factors in maternal serum during late pregnancy.

Authors:  T Saito; M Takada; N Ishida
Journal:  Tohoku J Exp Med       Date:  1975-05       Impact factor: 1.848

2.  Inhibition of mitogen induced blastogenesis by 5'-deoxy-5'-S-iso-butyl adenosine.

Authors:  C Bona; M Robert-Gero; E Lederer
Journal:  Biochem Biophys Res Commun       Date:  1976-05-17       Impact factor: 3.575

3.  Inhibition of lymphocyte stimulation by cyclic and non-cyclic nucleotides.

Authors:  G Estes; S S Solomon; W L Norton
Journal:  J Immunol       Date:  1971-11       Impact factor: 5.422

4.  Studies on the effect of nucleoside cyclic 3',5'-monophosphates on antibody synthesis by spleen cells.

Authors:  D Gericke; P Chandra; I Haenzel; A Wacker
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1970-03

5.  Competitive inhibition of beef heart cyclic AMP phosphodiesterase by cytokinins and related compounds.

Authors:  S M Hecht; R D Faulkner; S D Hawrelak
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

6.  Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin.

Authors:  R C Gallo; J Whang-Peng; S Perry
Journal:  Science       Date:  1969-07-25       Impact factor: 47.728

7.  Human lymphocytic metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin.

Authors:  J W Smith; A L Steiner; C W Parker
Journal:  J Clin Invest       Date:  1971-02       Impact factor: 14.808

  7 in total
  1 in total

1.  Presence and source of free isopentenyladenosine in yeasts.

Authors:  H M Laten; S Zahareas-Doktor
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

  1 in total

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