Literature DB >> 446658

Nerve-growth promoting action of isaxonine in rat.

A Hugelin, Y Legrain, M Bondoux-Jahan.   

Abstract

After sciatic nerve lesion by freezing, the length of the most rapidly regenerating fibres was significantly increased by i.p. injection of isaxonine (N-isopropyl-amino-2-pyrimidine orthophosphate) in the rat. A dose-effect relationship was demonstrated. Both sensory and motor function returned earlier in treated animals.

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Year:  1979        PMID： 446658     DOI： 10.1007/bf01960361

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  AN ELECTROPHYSIOLOGICAL STUDY OF THE EARLY STAGES OF PERIPHERAL NERVE REGENERATION.

Authors:  S JACOBSON; L GUTH
Journal:  Exp Neurol       Date:  1965-01       Impact factor: 5.330

2.  [Method for comparison of regeneration rate of fibres in the sciatic nerve of the rat [author's transl].

Authors:  Y Legrain
Journal:  J Physiol (Paris)       Date:  1977-06

3.  Effects of low temperature and colchicine on regenerating sciatic nerve.

Authors:  B Pinner-Poole; J B Campbell
Journal:  Exp Neurol       Date:  1969-12       Impact factor: 5.330

4.  [Acceleration of the speed of neuronal growth by a new neurotropic substance: N-isopropyl-amino-2-pyrimidine].

Authors:  A Hugelin; T Tarrade; M Istin; R Coelho
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1977-11-28
  4 in total
  4 in total

1.  Putative neurotrophic factors and functional recovery from peripheral nerve damage in the rat.

Authors:  C E Van der Zee; J H Brakkee; W H Gispen
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

2.  Muscle reinnervation enhanced by isaxonine in man.

Authors:  A Sebille; A Hugelin
Journal:  Br J Clin Pharmacol       Date:  1980-03       Impact factor: 4.335

3.  Treatment of peripheral neuropathies.

Authors:  M Hallett; D Tandon; A Berardelli
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-12       Impact factor: 10.154

4.  A study of the effects of isaxonine on vincristine-induced peripheral neuropathy in man and regeneration following peripheral nerve crush in the rat.

Authors:  P M Le Quesne; C J Fowler; A E Harding
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-09       Impact factor: 10.154
  4 in total

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