Literature DB >> 446644

Leonurine, an improved synthesis.

K F Cheng, C S Yip, H W Yeung, Y C Kong.   

Abstract

Leonurine (1) is the uterotonic principle of Leonurus artemisia. We have developed a simple, high-yield synthetic procedure of 1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1:1 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro.

Entities:  

Keywords:  Biology; Delivery Of Health Care; Genitalia; Genitalia, Female; Health; Health Services; Medicine; Physiology; Plants, Medicinal; Urogenital System; Uterus

Mesh：

Substances：

Year:  1979        PMID： 446644     DOI： 10.1007/bf01960323

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  AMINO-ACIDS AND PEPTIDES. XXII. SYNTHESIS OF N-ALPHA-L-ARGINYL-L-LYSYLGLYCINE.

Authors:  K B WALSHAW; G T YOUNG
Journal:  J Chem Soc       Date:  1965-01

2.  The sponge-tipped catheter--a modification of the open end catheter for recording of myometrial activity in vivo.

Authors:  L P Bengtsson
Journal:  J Reprod Fertil       Date:  1968-06

3.  The structure and biological effect of leonurine. A uterotonic principle from the Chinese drug, I-mu Ts'ao.

Authors:  H W Yeung; Y C Kong; W P Lay; K F Cheng
Journal:  Planta Med       Date:  1977-02       Impact factor: 3.352

4.  Isolation of the uterotonic principle from Leonurus artemisia, the Chinese motherwort.

Authors:  Y C Kong; H W Yeung; Y M Cheung; J C Hwang; Y W Chan; Y P Law; K H Ng; C H Yeung
Journal:  Am J Chin Med (Gard City N Y)       Date:  1976 WINTER
  4 in total
  1 in total

1.  Characterization of metabolites of leonurine (SCM-198) in rats after oral administration by liquid chromatography/tandem mass spectrometry and NMR spectrometry.

Authors:  Qing Zhu; Jinlian Zhang; Ping Yang; Bo Tan; Xinhua Liu; Yuanting Zheng; Weimin Cai; Yizhun Zhu
Journal:  ScientificWorldJournal       Date:  2014-02-24
  1 in total

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