Literature DB >> 446623

Effect of dichloromethane on the sciatic motor conduction velocity of rats.

D Pankow, R Gutewort, W Ponsold, W Glatzel, K Tietze.   

Abstract

There is a correlation between dichloromethane dosis (X) of 1--6 mmole/kg administered i.p. to rats and the sciatic motor conduction velocity (Y): Y = 57.1--1.091 X. The correlation coefficient 'r' is 0.437 (p less than 0.01). Presumably, the decrease of nerve conduction velocity is caused by the endogenous carbon monoxide production due to dichloromethane biotransformation.

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Year:  1979        PMID： 446623     DOI： 10.1007/bf01964361

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Fate and disposition of [ 14Ia1 methylene chloride in the rat.

Authors:  G D DiVincenzo
Journal:  Toxicol Appl Pharmacol       Date:  1975-05       Impact factor: 4.219

2.  The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats.

Authors:  B A Schwetz; K J Leong; P J Gehring
Journal:  Toxicol Appl Pharmacol       Date:  1975-04       Impact factor: 4.219

3.  Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.

Authors:  R P Roth; R T Drew; R J Lo; J R Fouts
Journal:  Toxicol Appl Pharmacol       Date:  1975-09       Impact factor: 4.219

4.  [Carbon tetrachloride in its effects on peripheral nerves (experimental study on rabbits)].

Authors:  W Glatzel; J W Grünes; K Tietze
Journal:  Z Gesamte Inn Med       Date:  1970-07-01

5.  In vivo conversion of methylene chloride to carbon monoxide.

Authors:  R S Ratney; D H Wegman; H B Elkins
Journal:  Arch Environ Health       Date:  1974-04

6.  [Rat motor neuron conduction rate after slight carboxyhemoglobinemia].

Authors:  W Ponsold; D Pankow; W Glatzel; K Tietze
Journal:  Z Gesamte Hyg       Date:  1977-01

7.  Effect of dichloromethane on hemoglobin function.

Authors:  H A Collison; F L Rodkey; J D O'Neal
Journal:  Biochem Pharmacol       Date:  1977-03-15       Impact factor: 5.858

8.  Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies.

Authors:  V L Kubic; M W Anders; R R Engel; C H Barlow; W S Caughey
Journal:  Drug Metab Dispos       Date:  1974 Jan-Feb       Impact factor: 3.922

9.  Alveolar air and blood dichloromethane concentration in shoe sole factory workers.

Authors:  L Perbellini; F Brugnone; L Grigolini; P Cunegatti; A Tacconi
Journal:  Int Arch Occup Environ Health       Date:  1977-12-22       Impact factor: 3.015

10.  [Increased blood-CO-content in humans and animals by incorporated halogenated hydrocarbons (author's transl)].

Authors:  G G Fodor; A Roscovanu
Journal:  Zentralbl Bakteriol Orig B       Date:  1976-07
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