Literature DB >> 446618

Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres.

J Tamargo, S Rodriguez.   

Abstract

Chlorimipramine (CMI, 1 x 10(-5)M to 7 X 10(-5)M) decreased the amplitude, overshoot and rate of rise of ventricular action potentials and abolished the Ca-mediated action potentials elicited in guinea-pig papillary muscles. These results indicates that CMI inhibits the rise in sodium and calcium conductances during the cardiac action potential.

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Year:  1979        PMID： 446618     DOI： 10.1007/bf01964356

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

Review 1.  A review of the cardiovascular effects and toxicity of tricyclic antidepressants.

Authors:  J W Jefferson
Journal:  Psychosom Med       Date:  1975 Mar-Apr       Impact factor: 4.312

2.  Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres.

Authors:  S WEIDMANN
Journal:  J Physiol       Date:  1955-09-28       Impact factor: 5.182

3.  Reconstruction of the action potential of ventricular myocardial fibres.

Authors:  G W Beeler; H Reuter
Journal:  J Physiol       Date:  1977-06       Impact factor: 5.182

4.  Electrophysiological effects of droperidol in different cardiac tissues.

Authors:  E Carmeliet; R Xhonneux; A Van Glabbeek; R Reneman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

5.  Clinical features in poisonings by tricyclic antidepressants with special reference to the ECG.

Authors:  C Thorstrand
Journal:  Acta Med Scand       Date:  1976

Review 6.  Divalent cations as charge carriers in excitable membranes.

Authors:  H Reuter
Journal:  Prog Biophys Mol Biol       Date:  1973       Impact factor: 3.667

7.  Cardiovascular abnormalities following tricyclic antidepressant drug overdosage.

Authors:  J K Vohra
Journal:  Drugs       Date:  1974       Impact factor: 9.546

8.  The slow inward current and the action of manganese ions in guinea-pig's myocardium.

Authors:  R Ochi
Journal:  Pflugers Arch       Date:  1970       Impact factor: 3.657

9.  Cardiac complications of tricyclic antidepressant therapy.

Authors:  R B Williams; C Sherter
Journal:  Ann Intern Med       Date:  1971-03       Impact factor: 25.391

10.  Membrane currents in mammalian ventricular heart muscle fibers using a voltage-clamp technique.

Authors:  G Giebisch; S Weidmann
Journal:  J Gen Physiol       Date:  1971-03       Impact factor: 4.086
  10 in total
  3 in total

Review 1.  Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?

Authors:  Pal Pacher; Valeria Kecskemeti
Journal:  Curr Pharm Des       Date:  2004       Impact factor: 3.116

2.  Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria.

Authors:  C Delgado; J Manzanares; J Tamargo; C Valenzuela
Journal:  Br J Pharmacol       Date:  1986-02       Impact factor: 8.739

3.  Inhibitory actions of amoxapine, a tricyclic antidepressant agent, on electrophysiological properties of mammalian isolated cardiac preparations.

Authors:  T Kinugawa; H Kotake; H Mashiba
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739
  3 in total

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