Literature DB >> 445851

A radioreceptor assay for diazepam and its metabolites in serum.

F Owen, R Lofthouse, R C Bourne.   

Abstract

A radioreceptor method is described for the estimation of serum concentrations of diazepam and its metabolites. The technique is simple, rapid and suitable for batch analysis. Ad advantage of the technique is that it gives a measure of the total pharmacological activity of the serum samples towards the benzodiazepine receptor and is thus directly applicable to benzodiazepines other than diazepam. The results obtained by the radioreceptor assay and by a GLC technique are correlated.

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Year:  1979        PMID: 445851     DOI: 10.1016/0009-8981(79)90279-1

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN: 0009-8981            Impact factor:   3.786


  2 in total

1.  The relationships between clinical response, psychophysiological variables and plasma levels of amitriptyline and diazepam in neurotic outpatients.

Authors:  E C Johnstone; R C Bourne; T J Crow; C D Frith; S Gamble; R Lofthouse; F Owen; D G Owens; J Robinson; M Stevens
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

2.  A radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites.

Authors:  R G Dorow; J Seidler; H H Schneider
Journal:  Br J Clin Pharmacol       Date:  1982-04       Impact factor: 4.335

  2 in total

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