| Literature DB >> 445419 |
A M Guarino, M Rozencweig, I Kline, J S Penta, J M Venditti, H H Lloyd, D A Holzworth, F M Muggia.
Abstract
Previous retrospective analyses have suggested a very positive correlation in toxic doses of antineoplastic agents between mice and humans. Additional toxicological information has now been accumulated and reveals a noticeable variability in the existing data base. Nevertheless, it is likely that mouse toxicological studies will become a principal determinant for estimating initial doses to be used in humans. Recognition of the factors responsible for differences in determinations of toxic dose levels in mice will enhance the proper utilization of this approach.Entities:
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Year: 1979 PMID： 445419
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701