Literature DB >> 4451767

Pulmonary mechanical effects of experimental lung embolism and their modification by bronchodilator drugs in the guinea-pig.

M J Daly.   

Abstract

In the anaesthetized guinea-pig micro-embolism induced by barium sulphate causes marked increases in pulmonary resistance and decreases in pulmonary compliance. Bronchodilator drugs prevent these changes with salbutamol showing much greater activity on pulmonary resistance changes than compliance changes. The results are discussed with regard to the site of action in the respiratory tree and potential clinical use.

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Year:  1974        PMID： 4451767      PMCID： PMC1778074          DOI： 10.1111/j.1476-5381.1974.tb09679.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  LOCATION AND MECHANISM OF AIRWAY CONSTRICTION AFTER BARIUM SULFATE MICROEMBOLISM.

Authors:  J A NADEL; J H COLEBATCH; C R OLSEN
Journal:  J Appl Physiol       Date:  1964-05       Impact factor: 3.531

2.  Ventilatory responses to embolization of lung.

Authors:  J M CAHILL; E O ATTINGER; J J BYRNE
Journal:  J Appl Physiol       Date:  1961-05       Impact factor: 3.531

3.  Cardiorespiratory effects of experimental lung embolism.

Authors:  D F HALMAGYI; H J COLEBATCH
Journal:  J Clin Invest       Date:  1961-09       Impact factor: 14.808

4.  Multiple embolism of the lung and rapid shallow breathing.

Authors:  D WHITTERIDGE
Journal:  Physiol Rev       Date:  1950-10       Impact factor: 37.312

5.  The comparative pharmacology of WG253 (rimiterol hydrobromide), a new bronchodilator.

Authors:  I Carney; M J Daly; J E Lightowler; R W Pickering
Journal:  Arch Int Pharmacodyn Ther       Date:  1971-12

6.  Pulmonary embolism.

Authors:  J E Dalen; L Dexter
Journal:  JAMA       Date:  1969-02-24       Impact factor: 56.272

7.  Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions.

Authors:  J E Mills; H Sellick; J G Widdicombe
Journal:  J Physiol       Date:  1969-08       Impact factor: 5.182

8.  Comparison of the bronchodilator and cardiovascular actions of salbutamol, isoprenaline and orciprenaline in guinea-pigs and dogs.

Authors:  M J Daly; J B Farmer; G P Levy
Journal:  Br J Pharmacol       Date:  1971-11       Impact factor: 8.739
  8 in total
  2 in total

1.  Role of platelets in aspirin-sensitive bronchoconstriction in the guinea-pig; interactions with salicylic acid.

Authors:  J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1978-05       Impact factor: 8.739

2.  Mechanisms of Forssman-induced bronchospasm and their inhibition.

Authors:  K D Butler; J R Smith
Journal:  Br J Pharmacol       Date:  1981-05       Impact factor: 8.739
  2 in total

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