Literature DB >> 4451341

Pharmacology of cephalothin in the biliary tract of humans.

J Mendelson, J Portnoy, H Sigman, V Dick.   

Abstract

Serum and biliary tract levels of cephalothin were determined in a large series of patients. Serum cephalothin levels in the therapeutic range were present at 1 h after a single dose of the antibiotic in only 4 of 39 (10.3%) subjects. Therapeutic bile cephalothin levels were achieved in only 2.4% of all subjects, and this occurred between 40 and 70 min after the administration of the antibiotic.

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Year:  1974        PMID： 4451341      PMCID： PMC444715          DOI： 10.1128/AAC.6.6.659

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  CEPHALOTHIN: ACTIVITY IN VITRO, ABSORPTION AND EXCRETION IN NORMAL SUBJECTS AND CLINICAL OBSERVATIONS IN 40 PATIENTS.

Authors:  J O KLEIN; T C EICKHOFF; J G TILLES; M FINLAND
Journal:  Am J Med Sci       Date:  1964-12       Impact factor: 2.378

2.  Cephalothin levels in human bile.

Authors:  M D Ram; S Watanatittan
Journal:  Arch Surg       Date:  1974-02

3.  The biliary excretion of cephalothin.

Authors:  J M Brogard; P Haegele; J J Kohler; M Dorner; J Lavillaureix; J Stahl
Journal:  Chemotherapy       Date:  1973       Impact factor: 2.544

4.  The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic.

Authors:  R Williams
Journal:  Proc R Soc Med       Date:  1969-03-03

5.  In vitro activity of cefazolin against recent clinical bacterial isolates.

Authors:  L D Sabath; C Wilcox; C Garner; M Finland
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

6.  An evaluation of antibiotics in biliary tract surgery.

Authors:  L J Pyrtek; S A Bartus
Journal:  Surg Gynecol Obstet       Date:  1967-07

7.  Clinical and in vitro evaluation of cefazolin, a new cephalosporin antibiotic.

Authors:  K Ries; M E Levison; D Kaye
Journal:  Antimicrob Agents Chemother       Date:  1973-02       Impact factor: 5.191
  7 in total
  1 in total

1.  Effects of cirrhosis on kinetics of aztreonam.

Authors:  C M MacLeod; E A Bartley; J A Payne; E Hudes; K Vernam; R G Devlin
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191
  1 in total

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