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Literature DB >> 4447856

Distribution of alpha- and beta-adrenoceptors in human urinary bladder.

S A Awad, A W Bruce, G Carro-Ciampi, J W Downie, M Lin, G S Marks.

Abstract

1 The distribution of alpha- and beta-adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied.2 Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol.3 Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine.4 Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol.5 It is concluded that the bladder neck contains mainly alpha-receptors and the detrusor mainly beta-receptors but both regions posses both types of adrenoceptor.

Entities: Chemical Species

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Year: 1974 PMID： 4447856 PMCID： PMC1776723 DOI： 10.1111/j.1476-5381.1974.tb08585.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

16 in total

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Journal: Am J Physiol Date: 1970-12

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Authors: W G Davis
Journal: J Pharm Pharmacol Date: 1970-04 Impact factor: 3.765

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Journal: Acta Physiol Scand Date: 1968 Jan-Feb

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Authors: C Raper; J Wale
Journal: Eur J Pharmacol Date: 1968-08 Impact factor: 4.432

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Authors: S Boyarsky; P Labay; R Gregg; B Levie
Journal: Paraplegia Date: 1968-11

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Authors: I M Coupar; P Turner
Journal: Br J Pharmacol Date: 1969-05 Impact factor: 8.739

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Journal: Acta Pharmacol Toxicol (Copenh) Date: 1969

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Authors: J K Todd; A J Mack
Journal: Br J Urol Date: 1969-08

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Authors: R Gjone
Journal: Acta Physiol Scand Date: 1966 Jan-Feb

10. Actions of phenylephrine on beta-adrenoceptors in guinea-pig trachea.

Authors: L A Chahl; S R O'Donnell
Journal: Br J Pharmacol Date: 1969-09 Impact factor: 8.739

14 in total

Review 1. Neuronal circuitry of the lower urinary tract; central and peripheral neuronal control of the micturition cycle.

Authors: M V Kinder; E H Bastiaanssen; R A Janknegt; E Marani
Journal: Anat Embryol (Berl) Date: 1995-09

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Journal: Drugs Date: 1988-10 Impact factor: 9.546

3. Prejudices in pharmacology and pharmacotherapy. The so-called anticholinergic effect of antidepressants.

Authors: H J Bein
Journal: Agents Actions Date: 1977-09

4. Pharmacological profile of the selective β3-adrenoceptor agonist mirabegron in cynomolgus monkeys.

Authors: Toshiki Hatanaka; Masashi Ukai; Mai Watanabe; Akiyoshi Someya; Akiyoshi Ohtake; Masanori Suzuki; Koji Ueshima; Shuichi Sato; Noriyuki Masuda
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2013-07-06 Impact factor: 3.000

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Authors: K E Creed
Journal: Br J Pharmacol Date: 1979-03 Impact factor: 8.739

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Authors: K Honda; A Miyata-Osawa; T Takenaka
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-07 Impact factor: 3.000