Literature DB >> 4447126

Arteriosclerosis due to homocyst (e) inemia. Failure to reproduce the model in weanling rabbits.

S Donahue, J A Struman, G Gaull.   

Abstract

Weanling rabbits were injected subcutaneously daily for 35 days with homocysteine thiolactone in an attempt to repeat the results of McCully and Ragsdale. We failed to produce sustained homocyst(e)inemia (or homocysteine thiolactonemia); indeed, transient homocyst(e)inemia could only be demonstrated with a much higher dose of the free base of homocysteine given intraperitoneally. Homocysteine thiolactonemia was observed up to 15 minutes, only after an intravenous injection of homocysteine thiolactone. Analysis of urine and various organs for free amino acids also failed to detect homocyst(e)ine or the thiolactone. Morphologically, we were unable to distinguish between the experimental and control animals.

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Year:  1974        PMID： 4447126      PMCID： PMC1910908     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  5 in total

1.  HOMOCYSTINURIA: A NEW INBORN ERROR OF METABOLISM ASSOCIATED WITH MENTAL DEFICIENCY.

Authors:  N A CARSON; D C CUSWORTH; C E DENT; C M FIELD; D W NEILL; R G WESTALL
Journal:  Arch Dis Child       Date:  1963-10       Impact factor: 3.791

2.  The identification of homocystine in the urine.

Authors:  T GERRITSEN; J G VAUGHN; H A WAISMAN
Journal:  Biochem Biophys Res Commun       Date:  1962-12-19       Impact factor: 3.575

3.  Production of arteriosclerosis by homocysteinemia.

Authors:  K S McCully; B D Ragsdale
Journal:  Am J Pathol       Date:  1970-10       Impact factor: 4.307

4.  A derangement in B 12 metabolism leading to homocystinemia, cystathioninemia and methylmalonic aciduria.

Authors:  S H Mudd; H L Levy; R H Abeles; J P Jennedy
Journal:  Biochem Biophys Res Commun       Date:  1969-04-10       Impact factor: 3.575

5.  Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

Authors:  K S McCully
Journal:  Am J Pathol       Date:  1969-07       Impact factor: 4.307
  5 in total
  5 in total

1.  Homocystinuria and the passing of the one gene-one enzyme concept of disease.

Authors:  G L Spaeth; G W Barber
Journal:  Trans Am Ophthalmol Soc       Date:  1978

Review 2.  Homocysteine and atherothrombosis.

Authors:  E Falk; J Zhou; J Møller
Journal:  Lipids       Date:  2001       Impact factor: 1.880

3.  Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

Authors:  L A Harker; R Ross; S J Slichter; C R Scott
Journal:  J Clin Invest       Date:  1976-09       Impact factor: 14.808

4.  Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.

Authors:  Ji Zhou; Geoff H Werstuck; Sárka Lhoták; Yuan Y Shi; Vivienne Tedesco; Bernardo Trigatti; Jeffrey Dickhout; Alana K Majors; Patricia M DiBello; Donald W Jacobsen; Richard C Austin
Journal:  FASEB J       Date:  2008-03-25       Impact factor: 5.191

5.  A study of cardiovascular risk in heterozygotes for homocystinuria.

Authors:  S H Mudd; R Havlik; H L Levy; V A McKusick; M Feinleib
Journal:  Am J Hum Genet       Date:  1981-11       Impact factor: 11.025
  5 in total

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