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Literature DB >> 444668

Transport accounts for glutathione turnover in human erythrocytes.

Abstract

Human erythrocytes were incubated with 3H-glycine to label the glutathione pool. These cells were then used to determine the rate of oxidized glutathione (GSSG) transport out of erythrocytes. For 6 normal individuals, the mean transport rate was 6.7 nmole GSSG/hr/ml red cells. This transport rate would suggest a half-life of 4.7 days for the erythrocytic glutathione, which is in close agreemwnt with the observed in vivo half-life of 4 days. These data demonstrate that GSSG transport can account for the observed turnover of erythrocytic glutathione.

Entities: Chemical Species

Mesh：

Substances：
Glutathione

Year: 1979 PMID： 444668

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

12 in total

Review 1. Thioredoxin and glutathione system of malaria parasite Plasmodium falciparum.

Authors: S Müller; T W Gilberger; Z Krnajski; K Lüersen; S Meierjohann; R D Walter
Journal: Protoplasma Date: 2001 Impact factor: 3.356

2. Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione.

Authors: K Lüersen; R D Walter; S Müller
Journal: Biochem J Date: 2000-03-01 Impact factor: 3.857

3. Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data.

Authors: Julia E Raftos; Stephney Whillier; Philip W Kuchel
Journal: J Biol Chem Date: 2010-05-24 Impact factor: 5.157

4. Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.

Authors: Yvonne Lamers; Bruce O'Rourke; Lesa R Gilbert; Christine Keeling; Dwight E Matthews; Peter W Stacpoole; Jesse F Gregory
Journal: Am J Clin Nutr Date: 2009-06-10 Impact factor: 7.045

5. Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux.

Authors: K Yoshida; J Hirokawa; S Tagami; Y Kawakami; Y Urata; T Kondo
Journal: Diabetologia Date: 1995-02 Impact factor: 10.122

Transport accounts for glutathione turnover in human erythrocytes.

Review 1. Thioredoxin and glutathione system of malaria parasite Plasmodium falciparum.

2. Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione.

3. Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data.

4. Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.

5. Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux.

6. Hepatic efflux and renal extraction of plasma glutathione: marked differences between healthy subjects and the rat.

7. Glutathione biosynthesis in the aging adult yellow-fever mosquito [Aedes aegypti (Louisville)].

8. Glutathione disulfide-stimulated Mg2+-ATPase of human erythrocyte membranes.

9. Glutathione transport by inside-out vesicles from human erythrocytes.

10. Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance.