Literature DB >> 444328

Hepatomegaly due to self-induced hyperinsulinism.

J Asherov, M Mimouni, I Varsano, E Lubin, Z Laron.   

Abstract

Repeated hypoglycaemic attacks, associated with transient hepatomegaly, in a 12-year-old insulin-dependent diabetic girl continued despite reduction in dose and, later, complete discontinuance of insulin. The attacks ceased while she was in hospital, necessitating reinstitution of insulin. The hepatomegaly resolved when surreptitious additional insulin injections were discovered and stopped. Hepatomegaly in diabetics should arouse suspicion of overdosage with insulin.

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Year:  1979        PMID: 444328      PMCID: PMC1545374          DOI: 10.1136/adc.54.2.148

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN: 0003-9888            Impact factor:   3.791


  9 in total

1.  EFFECTS OF INSULIN ON LIVER GLYCOGEN SYNTHESIS AND BREAKDOWN IN THE DOG.

Authors:  J S BISHOP; R STEELE; N ALTSZULER; A DUNN; C BJERKNES; R C DEBODO
Journal:  Am J Physiol       Date:  1965-02

2.  INHIBITION BY INSULIN OF HEPATIC GLUCOSE PRODUCTION IN THE NORMAL DOG.

Authors:  R STEELE; J S BISHOP; A DUNN; N ALTSZULER; I RATHBEB; R C DEBODO
Journal:  Am J Physiol       Date:  1965-02

3.  Chronic overtreatment with insulin in children and adolescents.

Authors:  A L Rosenbloom; B P Giordano
Journal:  Am J Dis Child       Date:  1977-08

4.  The Mauriac syndrome.

Authors:  F Mandell; W Berenberg
Journal:  Am J Dis Child       Date:  1974-06

5.  Acute effects of insulin on carbohydrate metabolism in rat liver slices: independence from glucagon.

Authors:  M B Davidson; J A Berliner
Journal:  Am J Physiol       Date:  1974-07

Review 6.  Role of insulin in the hepatic handling of glucose.

Authors:  L L Madison
Journal:  Arch Intern Med       Date:  1969-03

7.  Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.

Authors:  L S Jefferson; J H Exton; R W Butcher; E W Sutherland; C R Park
Journal:  J Biol Chem       Date:  1968-03-10       Impact factor: 5.157

8.  Effects of insulin on net carbohydrate alterations in perfused rat liver.

Authors:  G E Mortimore; E King; C E Mondon; W H Glinsmann
Journal:  Am J Physiol       Date:  1967-01

9.  Transient hepatomegaly and hypoglycemia. A consequence of malicious insulin administration.

Authors:  R Dershewitz; B Vestal; N K Maclaren; M Cornblath
Journal:  Am J Dis Child       Date:  1976-09
  9 in total
  1 in total

1.  NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.

Authors:  Feng He; Laura Antonucci; Shinichiro Yamachika; Zechuan Zhang; Koji Taniguchi; Atsushi Umemura; Georgia Hatzivassiliou; Merone Roose-Girma; Miguel Reina-Campos; Angeles Duran; Maria T Diaz-Meco; Jorge Moscat; Beicheng Sun; Michael Karin
Journal:  J Hepatol       Date:  2020-02-24       Impact factor: 25.083

  1 in total

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