| Literature DB >> 4441387 |
R J Olson, T E Trumble, W Gamble.
Abstract
2,4-Dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid inhibited the incorporation of [2-(14)C]mevalonate into cholesterol and non-saponifiable lipids. Both compounds inhibited the conversion of [1-(14)C]isopentenyl pyrophosphate into cholesterol and the synthesis of cholesterol and fatty acids from [2-(14)C]acetate. There was no inhibition of the conversion of [1-(14)C]mevalonate into CO(2). At low concentrations (0.5mm) of the compounds there was a stimulation of acetate incorporation into fatty acids.Entities:
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Year: 1974 PMID： 4441387 PMCID： PMC1168299 DOI： 10.1042/bj1420445
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857