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Literature DB >> 4441386

Peroxidatic oxidation of tyrosine to melanin in supernatant of crude mouse melanoma homogenates.

R P Patel, M R Okun, L M Edelstein, N Cariglia.

Abstract

Peroxide-dependent enzymic oxidation of tyrosine to dopachrome and melanin was demonstrated in cell-free melanoma homogenates. Histochemical methods for distinguishing peroxidase activity from aerobic dopa (3,4-dihydroxyphenylalanine) oxidase activity are not reliable with cell-free preparations. Therefore the presence of peroxidase activity in such preparations precludes assay of cresolase activity of mammalian ;tyrosinase'.

Entities: Chemical Disease Species

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Year: 1974 PMID： 4441386 PMCID： PMC1168298 DOI： 10.1042/bj1420441

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

16 in total

1. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors: B J DAVIS
Journal: Ann N Y Acad Sci Date: 1964-12-28 Impact factor: 5.691

2. Partial purification and kinetic studies of mammalian tyrosinase.

Authors: K SHIMAO
Journal: Biochim Biophys Acta Date: 1962-08-13

3. Inability of murine melanoma "tyrosinase" (dopa ozidase) to oxidize tyrosine in the presence or absence of dopa or dihydroxyfumarate cofactor.

Authors: R P Patel; M R Okun; W A Yee; G F Wilgram; L M Edelstein
Journal: J Invest Dermatol Date: 1973-08 Impact factor: 8.551

4. Subcellular demonstration of peroxidatic oxidation of tyrosine to melanin using dihydroxyfumarate as cofactor in mouse melanoma cells.

Authors: M R Okun; B Donnellan; R P Patel; L M Edelstein
Journal: J Invest Dermatol Date: 1973-08 Impact factor: 8.551

5. Incorporation of tyrosine carboxyl groups and utilization of D-tyrosine in melanogenesis.

Authors: Y M Chen; W Chavin
Journal: Anal Biochem Date: 1969-03 Impact factor: 3.365

6. DOPA compared with dihydroxyfumarate as co-factor in peroxidase-mediated oxidation of tyrosine to melanin. Histochemical studies with neutrophils, eosinophils, mast cells, melanoma cells and neurons.

Authors: M R Okun; R P Patel; B Donnellan; W F Lever; L M Edelstein; D Epstein
Journal: Histochemie Date: 1971

7. Biochemical studies of the peroxidase-mediated oxidation of tyrosine to melanin: demonstration of the hydroxylation of tyrosine by plant and human peroxidases.

Authors: R P Patel; M R Okun; L M Edelstein; D Epstein
Journal: Biochem J Date: 1971-09 Impact factor: 3.857

Peroxidatic oxidation of tyrosine to melanin in supernatant of crude mouse melanoma homogenates.

1. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

2. Partial purification and kinetic studies of mammalian tyrosinase.

3. Inability of murine melanoma "tyrosinase" (dopa ozidase) to oxidize tyrosine in the presence or absence of dopa or dihydroxyfumarate cofactor.

4. Subcellular demonstration of peroxidatic oxidation of tyrosine to melanin using dihydroxyfumarate as cofactor in mouse melanoma cells.

5. Incorporation of tyrosine carboxyl groups and utilization of D-tyrosine in melanogenesis.

6. DOPA compared with dihydroxyfumarate as co-factor in peroxidase-mediated oxidation of tyrosine to melanin. Histochemical studies with neutrophils, eosinophils, mast cells, melanoma cells and neurons.

7. Biochemical studies of the peroxidase-mediated oxidation of tyrosine to melanin: demonstration of the hydroxylation of tyrosine by plant and human peroxidases.

8. Histochemical studies of conversion of tyrosine and DOPA to melanin mediated by mammalian peroxidase.

9. Peroxidase activity in normal and neoplastic melanocytes.

10. Cytochemical localization of peroxidatic activity of catalase in rat hepatic microbodies (peroxisomes).

1. Tyrosinase activity in human skin. Influence of race and age in newborns.