Literature DB >> 44373

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.

M Stanley, J Rotrosen, N Sculerati, S Gershon, C Kuhn, B M Cohen.   

Abstract

The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

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Year:  1979        PMID： 44373     DOI： 10.1007/bf00431984

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  20 in total

1.  Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency.

Authors:  G Langer; E J Sachar; P H Gruen; F S Halpern
Journal:  Nature       Date:  1977-04-14       Impact factor: 49.962

2.  Antipsychotic drug doses and neuroleptic/dopamine receptors.

Authors:  P Seeman; T Lee; M Chau-Wong; K Wong
Journal:  Nature       Date:  1976-06-24       Impact factor: 49.962

3.  Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.

Authors:  I Creese; D R Burt; S H Snyder
Journal:  Science       Date:  1976-04-30       Impact factor: 47.728

Review 4.  Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

Authors:  S Matthysse
Journal:  Fed Proc       Date:  1973-02

5.  Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats.

Authors:  P A Janssen; C J Niemegeers; K H Schellekens; F M Lenaerts
Journal:  Arzneimittelforschung       Date:  1967-07

6.  Simultaneous determination of 3,4-dihydroxyphenylacetic acid and homovanillic acid in milligram amounts of rat striatal tissue by gas-liquid chromatography.

Authors:  E Watson; B Travis; S Wilk
Journal:  Life Sci       Date:  1974-12-15       Impact factor: 5.037

7.  The effect of antipsychotic drugs and their clinically inactive analogs on dopamine metabolism.

Authors:  M Stanley; S Wilk
Journal:  Eur J Pharmacol       Date:  1977-08-15       Impact factor: 4.432

8.  Clozapine and the dopamine hypothesis of schizophrenia, a critical appraisal.

Authors:  H R Bürki; E Eichenberger; A C Sayers; T G White
Journal:  Pharmakopsychiatr Neuropsychopharmakol       Date:  1975-05

9.  Differential sensitivity of two dopaminergic structures in rat brain to haloperidol and to clozapine.

Authors:  S Wilk; E Watson; M E Stanley
Journal:  J Pharmacol Exp Ther       Date:  1975-11       Impact factor: 4.030

10.  Perlapine: relationship between stimulation of prolactin secretion and antipsychotic activity.

Authors:  H Y Meltzer; R G Fessler; V S Fang
Journal:  Psychopharmacology (Berl)       Date:  1977-10-20       Impact factor: 4.530
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  1 in total

1.  A double-blind comparison of trebenzomine and thioridazine in the treatment of schizophrenia.

Authors:  A Georgotas; L Gerbino; B Jordan; M McCarthy; S Gershon; D Kleinberg; A Lautin; M Stanley; J Rotrosen
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530
  1 in total

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