Literature DB >> 4435102

A potent antihypercholesterolemic agent: (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio) acetic acid (Wy-14643).

A A Santilli, A C Scotese, R M Tomarelli.   

Abstract

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Year:  1974        PMID： 4435102     DOI： 10.1007/BF01923636

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


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  1 in total

Review 1.  Hypolipidemic agents.

Authors:  W L Bencze; R Hess; G DeStevens
Journal:  Prog Drug Res       Date:  1969
  1 in total
  11 in total

1.  Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis.

Authors:  S Parthasarathy; D Kritchevsky; W J Baumann
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

2.  Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.

Authors:  S S Lee; T Pineau; J Drago; E J Lee; J W Owens; D L Kroetz; P M Fernandez-Salguero; H Westphal; F J Gonzalez
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

3.  Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae.

Authors:  Shuhao Yu; Zhizhong Guo; Yan Guan; Yi-Yu Lu; Pei Hao; Yixue Li; Shi-Bing Su
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-14       Impact factor: 2.629

4.  Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates.

Authors:  Johan Nyström-Persson; Yayoi Natsume-Kitatani; Yoshinobu Igarashi; Daisuke Satoh; Kenji Mizuguchi
Journal:  Sci Rep       Date:  2017-05-03       Impact factor: 4.379

5.  Characterization of WY 14,643 and its Complex with Aldose Reductase.

Authors:  Michael R Sawaya; Malkhey Verma; Vaishnavi Balendiran; Nigam P Rath; Duilio Cascio; Ganesaratnam K Balendiran
Journal:  Sci Rep       Date:  2016-10-10       Impact factor: 4.379

6.  Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121).

Authors:  Matthias Gabler; Manfred Schubert-Zsilavecz
Journal:  Molecules       Date:  2011-12-05       Impact factor: 4.411

Review 7.  Benzotriazole: An overview on its versatile biological behavior.

Authors:  I Briguglio; S Piras; P Corona; E Gavini; M Nieddu; G Boatto; A Carta
Journal:  Eur J Med Chem       Date:  2014-09-30       Impact factor: 6.514

8.  PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB.

Authors:  Wanshun Wen; Jinlin Wang; Biyu Zhang; Jun Wang
Journal:  PPAR Res       Date:  2020-12-14       Impact factor: 4.964

9.  Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport.

Authors:  Martin Michaelis; Florian Rothweiler; Mario Wurglics; Natália Aniceto; Michaela Dittrich; Heiko Zettl; Michael Wiese; Mark Wass; Taravat Ghafourian; Manfred Schubert-Zsilavecz; Jindrich Cinatl
Journal:  Oncotarget       Date:  2016-03-08

10.  Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro.

Authors:  Pascal Heitel; Leonie Gellrich; Jan Heering; Tamara Goebel; Astrid Kahnt; Ewgenij Proschak; Manfred Schubert-Zsilavecz; Daniel Merk
Journal:  Sci Rep       Date:  2018-09-10       Impact factor: 4.379
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